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TranscriptomicsMyeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence
Tissue stem cells are hierarchically organized, but the signals that selectively preserve their functional integrity are largely unknown. Semaphorin 4A (Sema4A) is a specific regulator of myeloid-biased hematopoietic stem cells (myHSC), which are positioned at the top of the HSC hierarchy. Through s...
ORGANISM(S): Mus musculus 
2023-06-04 | E-MTAB-12890 | biostudies-arrayexpress
TranscriptomicsMyeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence
Tissue stem cells are hierarchically organized, but the signals that selectively preserve their functional integrity are largely unknown. Semaphorin 4A (Sema4A) is a specific regulator of myeloid-biased hematopoietic stem cells (myHSC), which are positioned at the top of the HSC hierarchy. Through...
ORGANISM(S): Mus musculus 
2022-01-21 | E-MTAB-11359 | biostudies-arrayexpress
TranscriptomicsDazl is required for TET-mediated reprogramming to a naïve pluripotent state (I)
Embryonic stem cell (ESC) cultures display a heterogeneous gene expression profile, ranging from a pristine naïve pluripotent state to a primed epiblast state. While it is known that the addition of inhibitors of GSK3? and MEK (so-called 2i conditions) push ESC cultures towards a more homogeneous na...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-69055 | biostudies-arrayexpress
TranscriptomicsIn Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling
Primary leukemia stem cells (LSCs) reside in an in vivo microenvironment that supports the growth and survival of malignant cells. We used an in vivo short hairpin RNA (shRNA) screening approach to identify novel genes that are essential for primary murine MLL-AF9 acute myeloid leukemia (AML). We fo...
ORGANISM(S): Mus musculus 
2013-04-24 | E-GEOD-46307 | biostudies-arrayexpress
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