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ProteomicsTankyrase-mediated ADP-ribosylation is a novel regulator of TNF-induced death
TNF is a key component of the innate immune response. Upon binding to its receptor, TNFR1, it promotes production of other cytokines via a membrane-bound complex 1, or induces cell death via a cytosolic complex 2. To understand how TNF-induced cell death is regulated we performed mass spectrometry o...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD032131 | Pride
Tnf-induced cell death Tankyrase Adp-ribosylation 
UnknownTargeting triple-negative breast cancers with the Smac-mimetic birinapant.
Not available
S-EPMC7492458 | biostudies-literature
UnknownMK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.
Not available
S-EPMC5459754 | biostudies-literature
UnknownUbiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.
Not available
S-EPMC5823975 | biostudies-literature
UnknownCombination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.
Not available
S-EPMC5344208 | biostudies-literature
UnknownA missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.
Not available
S-EPMC7305203 | biostudies-literature
TranscriptomicsAssociation of genes regulated by Ezh2 and trimethylation of histone 3 lysine 27
Differentiation of naïve CD4+ T cells into effector (Th1, Th2 and Th17) and induced regulatory (iTreg) T cells requires lineage-specifying transcription factors and epigenetic modifications that allow appropriate repression or activation of gene transcription. The epigenetic silencing of cytokine ge...
ORGANISM(S): Mus musculus 
2014-08-04 | E-GEOD-57500 | biostudies-arrayexpress
UnknownA common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.
Not available
S-EPMC10539340 | biostudies-literature
UnknownRIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
Not available
S-EPMC6375735 | biostudies-literature
UnknowncIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation
Not available
S-SCDT-10_15252-EMBJ_2023113614 | biostudies-other
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