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ProteomicsHuman Tankyrases TAP-LC-MSMS - Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy
Tankyrase 1 (TNKS1) and tankyrase 2 (TNKS2) belong to the poly(ADP-ribose) polymerase (PARP) family of proteins, which use NAD+ to modify substrate proteins with ADP-ribose modifications. Tankyrases are implicated involving in multiple cellular functions, including the telomere length control, Wnt/b...
ORGANISM(S): Homo sapiens (Human) 
2017-07-24 | PXD004647 | Pride
Human Lc-msms Tankyrase Tap 
ProteomicsIdentification of response signatures for tankyrase inhibitor treatment in tumor cell lines
Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective anti-tumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the anti-proliferative effect of tankyrase inhibition (TNKSi). The TNKS1/2-spe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022908 | Pride
Cancer Tankyrase Silac 
ProteomicsTankyrase modulates insulin sensitivity in skeletal muscle cells by regulating stability of GLUT4 vesicle proteins
Tankyrase1 and 2, members of the poly(ADP-ribose) polymerase family, play a role in multiple biological processes including Wnt signalling and glucose uptake. However, their role in glucose uptake remains elusive, particularly in skeletal muscle cells. Treatment of differentiated L6 myotubes with th...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-04-17 | PXD007182 | Pride
Gsv Tankyrase Skeletal muscle 
GenomicsGene expression profiling of tankyrase-inhibited mouse articular chondrocytes
Gene expression profiling of tankyrase-inhibited mouse articular chondrocytes
PRJNA573735 | ENA
TranscriptomicsHGPalmer-PDX-NVP-TNKS656
Strong activation of the oncogenic Wnt/beta-catenin pathway is a main mechanism of resistance to FOXO3a-induced apoptosis promoted by PI3K and AKT inhibitors in colorectal cancer (CRC). Reducing Wnt/beta-catenin activity would sensitize colorectal tumors to these inhibitors. However, no Wnt/beta-cat...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-MTAB-2446 | biostudies-arrayexpress
ProteomicsTankyrase-mediated ADP-ribosylation is a novel regulator of TNF-induced death
TNF is a key component of the innate immune response. Upon binding to its receptor, TNFR1, it promotes production of other cytokines via a membrane-bound complex 1, or induces cell death via a cytosolic complex 2. To understand how TNF-induced cell death is regulated we performed mass spectrometry o...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD032131 | Pride
Tnf-induced cell death Tankyrase Adp-ribosylation 
ProteomicsProteomic analysis reveals multiple targets of tankyrase-mediated degradation
To identify targets of tankyrase 1 and 2 we established a double knock out HEK293T cell line. We compared the proteins in WT versus the double knock out applying a relative quantitation method using TMT tags and off-line fractionation of the proteome.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-02 | MSV000081663 | MassIVE
UnknownStructural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.
Not available
S-EPMC5980575 | biostudies-literature
GenomicsGene expression data of colorectal cancer patient-derived cells treated with tankyrase inhibitors
Gene expression data of colorectal cancer patient-derived cells treated with tankyrase inhibitors
PRJNA900266 | ENA
TranscriptomicsGene expression profiling of tankyrase-inhibited mouse articular chondrocytes
Osteoarthritis (OA) is a prevalent degenerative disease, which involves progressive and irreversible destruction of cartilage matrix. Despite efforts to reconstruct cartilage matrix in osteoarthritic joints, it has been a difficult task as adult cartilage exhibits marginal repair capacity. Here we r...
ORGANISM(S): Mus musculus 
2019-09-24 | GSE137899 | GEO
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