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MetabolomicsComprehensive lipid analysis of green Arabica coffee beans by LC-HRMS/MS
Lipids play an important role in coffee bean development, coffee brew and in the effects of coffee on human health. They account for around 17% of the dry bean weight and encompass different classes and subclasses, mostly triacylglycerols (TAG) and a minor quantity of phospholipids (PL) and βN-alkan...
2021-11-19 | MTBLS1972 | MetaboLights
MetabolomicsEpithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice an...
2018-08-13 | MTBLS523 | MetaboLights
MetabolomicsAge-related differences in the gut microbiota and plasma metabolome in dogs: a prospective cross-sectional study under standardized dietary conditions
Background: Aging is associated with progressive metabolic and physiological changes that influence health span in humans and may similarly impact dogs. This study aimed to characterize in the gut microbiota and their associations with host metabolism. Client-owned young adult (2-5 years, > 20 kg, n...
2026-06-26 | MTBLS14861 | MetaboLights
ProteomicsMOI analysis of purslane responses to salinity stress - roots
This project constructed a multiomics (proteome, metabolome, and transcriptome) database on the response of purslane (Portulaca oleracea L.) plants to salt stress and subsequently started to employ Single-omics (SOA) and Multi-omics Integration (MOI) strategies to characterize the molecular basis of...
ORGANISM(S): Portulaca oleracea 
2023-06-01 | PXD041628 | Pride
Portulaca oleracea Mult omics integration Salt stress 
ProteomicsMOI analysis of purslane responses to salinity stress - leaf
This project constructed a multiomics (proteome, metabolome, and transcriptome) database on the response of purslane (Portulaca oleracea L.) plants to salt stress and subsequently started to employ Single-omics (SOA) and Multi-omics Integration (MOI) strategies to characterize the molecular basis of...
ORGANISM(S): Portulaca oleracea 
2023-06-01 | PXD041627 | Pride
Portulaca oleracea Salinity stress Mult omics integration 
ProteomicsTime-resolved proteomic profile of Amblyomma americanum tick saliva during feeding Running Title: Proteins in tick saliva every 24 h during feeding
Pioneering studies (PXD014844) have identified many interesting molecules by LC-MS/MS proteomics, but the protein databases used to assign mass spectra were based on short Illumina reads of the Amblyomma americanum transcriptome and may not have captured the diversity and complexity of longer transc...
ORGANISM(S): Amblyomma americanum 
2020-01-23 | PXD014844 | Pride
Tick-feeding Ticks Saliva Proteome 
ProteomicsTick host range adaptation: changes in protein profiles in Ixodes scapularis and Amblyomma americanum saliva during stimulation to feed on different hosts
Understanding the molecular basis of how the tick adapts to feed on different animal hosts is central to understanding tick and tick-borne disease (TBD) epidemiology. Tick adaptation to feed on vertebrate hosts is regulated by tick secretion of multiple tick saliva proteins (TSPs) and other molecule...
ORGANISM(S): Ixodes scapularis (Black-legged tick) (Deer tick) Amblyomma americanum 
2022-02-28 | PXD007712 | Pride
Tick-host relationship Saliva Tick Proteomic Host adaptation 
MetabolomicsA pathogen-specific isotope tracing approach reveals metabolic activities and fluxes of intracellular Salmonella

Pathogenic bacteria proliferating inside mammalian host cells need to rapidly adapt to the intracellular environment. How they achieve this and scavenge essential nutrients from the host has been an open question due to the difficulties in distinguishing between bacterial and host metabolites

2023-08-02 | MTBLS1275 | MetaboLights
ProteomicsMycobacterium smegmatis cultured in different carbon sources to induce in vitro cholesterol consumption reveals alterations in immune response after infection: a macrophage proteomics analysis.
During Tuberculosis, Mycobacterium uses host macrophage cholesterol as a carbon and energy source. To mimic these conditions Mycobacterium smegmatis cultured in minimal medium (MM) has been used to induce cholesterol consumption in vitro. During cultivation, M. smegmatis con-sumes MM cholesterol and...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025783 | Pride
Mycobacterium  proteomics  cholesterol  infection  macrophages. 
TranscriptomicsRNA-seq of mouse embryonic stem cells with knockout of Nhlrc2 gene or addition of FINCA disease causing NHLRC2 p.Asp148Tyr variant
Fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA) (OMIM 618278) is a rare infantile-onset disease caused by variants in NHL repeat containing 2 (NHLRC2) gene. NHLRC2 is essential for mouse gastrulation (Hiltunen et al., 2022). Here, RNA sequencing was performed on four wild type (WT), f...
ORGANISM(S): Mus musculus 
2025-05-22 | E-MTAB-14174 | biostudies-arrayexpress
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