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TranscriptomicsCD133/CD140a-Based Isolation of Distinct Human Multipotent Neural Progenitor Cells and Oligodendrocyte Progenitor Cells
The mechanisms underlying the specification of oligodendrocyte fate from multipotent neural progenitor cells (NPCs) in developing human brain are unknown. In this study, we sought to identify antigens sufficient to distinguish NPCs free from oligodendrocyte progenitor cells (OPCs). We investigated t...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-40676 | biostudies-arrayexpress
TranscriptomicsIsolation of fetal human CD140a and O4-defined oligodendrocyte progenitor cells.
Human fetal tissue dissociates between 18-22wk gestational age were FACS sorted on the basis of CD140a (PDGFRA) and O4 antigens. Each population was profiled immediately following FACS. 20 samples, 4 groups (FACS-sorted cell populations), between 3 and 6 replicates in each group, each replicate is f...
ORGANISM(S): Homo sapiens 
2015-03-04 | E-GEOD-32589 | biostudies-arrayexpress
TranscriptomicsComplementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation.
OBJECTIVE: Glial progenitor cells are abundant in adult human white matter. This study was designed to identify signaling pathways regulating their self-renewal and fate. METHODS: We compared the transcriptional profiles of freshly sorted adult human white matter progenitor cells (WMPCs), purified ...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-26535 | biostudies-arrayexpress
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