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TranscriptomicsTranscription profiling of liver from mice with constitutively active Hypoxia Inducible Factor (HIF-1a and HIF-2a) or inactivated von Hippel-Lindau tumor suppressor gene product (pVHL)
The effects of constitutively active Hypoxia Inducible Factor (HIF) and inactivated von Hippel-Lindau tumor suppressor gene product (pVHL) were examined in a mouse model. Conditionally expressed, constitutively active HIF-1a and HIF-2a were compared with inactivated pVHL.
ORGANISM(S): Mus musculus 
2006-09-21 | E-MEXP-856 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse B16-F10 cells exposed to hypoxic conditions in vitro.
Analysis of gene expression profile of B16-F10 murine melanoma cells exposed to hypoxic conditions (1% oxygen) or hypoxia mimicry (cobalt chloride) for 24 hours. Gene expression profiles were analyzed using MG-U74Av2 oligonucleotide microarrays. Data analysis revealed 2541 probesets (FDR<5%) for 1...
ORGANISM(S): Mus musculus 
2011-11-11 | E-GEOD-33607 | biostudies-arrayexpress
TranscriptomicsLow-power photodynamic therapy induces survival signaling in cultured hilar cholangiocarcinoma cells
Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizerreplete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and inducti...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-68292 | biostudies-arrayexpress
TranscriptomicsRNA-seq of small intestine tissues from VHL(fl/fl) and Ncr1(Cre)VHL(fl/fl) mice
Global alterations in gene expression in the small intestine triggered by HIF-1a activation in NKp46+ cells.
ORGANISM(S): Mus musculus 
2021-12-10 | E-MTAB-11212 | biostudies-arrayexpress
TranscriptomicsRNA-seq of small intestine tissues from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice
Global alterations in gene expression in the small intestine triggered by HIF-1a loss in NKp46+ cells.
ORGANISM(S): Mus musculus 
2021-12-10 | E-MTAB-11213 | biostudies-arrayexpress
TranscriptomicsRNA-seq of colonic tissues from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice
Global alterations in gene expression in the colon triggered by HIF-1a loss in NKp46+ cells.
ORGANISM(S): Mus musculus 
2021-12-10 | E-MTAB-11214 | biostudies-arrayexpress
TranscriptomicsRNA-seq of colonic tissues at day 4 post Dextran sulfate sodium (DSS)-induced colitis from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice.
Global alterations in gene expression in the damaged colon triggered by HIF-1a loss in NKp46+ cells.
ORGANISM(S): Mus musculus 
2021-12-10 | E-MTAB-11215 | biostudies-arrayexpress
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
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