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TranscriptomicsA critical role of microRNAs in human pulmonary arterial hypertension. miR-204: a novel therapeutic target (TaqMan qPCR)
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed apoptosis. Downregulation of the BMPR2 gene along with activation of the transcription factor NFAT have been implicated in the mai...
ORGANISM(S): Homo sapiens 
2010-12-16 | E-GEOD-21281 | biostudies-arrayexpress
TranscriptomicsFunction, targets and evolution of Caenorhabditis elegans piRNAs (small RNA-Seq)
piRNAs are required to maintain germline integrity and fertility but their mechanism of action is poorly understood. Here we demonstrate that C. elegans piRNAs silence transcripts in trans through imperfectly complementary sites. We find that target silencing is independent of Piwi endonuclease acti...
ORGANISM(S): Caenorhabditis elegans 
2012-06-18 | E-GEOD-28617 | biostudies-arrayexpress
UnknownProspective evaluation of a breast-cancer risk model integrating classical risk factors and polygenic risk in 15 cohorts from six countries.
Not available
S-EPMC8743128 | biostudies-literature
UnknownImmediate effect of the COVID-19 pandemic on patient health, health-care use, and behaviours: results from an international survey of people with rheumatic diseases.
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S-EPMC8298011 | biostudies-literature
Unknown2023 Canadian Surgery Forum: Sept. 20-23, 2023.
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S-EPMC10718225 | biostudies-literature
UnknownAccuracy of the Hospital Anxiety and Depression Scale Depression subscale (HADS-D) to screen for major depression: systematic review and individual participant data meta-analysis.
Not available
S-EPMC8107836 | biostudies-literature
UnknownCommon variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Not available
S-EPMC3319317 | biostudies-literature
UnknownAssociation of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3.
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S-EPMC5222911 | biostudies-literature
UnknownPhysical activity, sedentary time and breast cancer risk: a Mendelian randomisation study.
Not available
S-EPMC9876601 | biostudies-literature
UnknownCommon variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers.
Not available
S-EPMC3496151 | biostudies-literature
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