Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study.

ABSTRACT:

Objectives

Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.

Methods

We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide

SUBMITTER: Dixon-Suen SC 

PROVIDER: S-EPMC9876601 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature