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TranscriptomicsVariation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects
Comprehensive sequencing of human cancers has identified recurrent mutations in genes encoding chromatin regulatory proteins. For clear cell renal cell carcinoma (ccRCC), three of the five commonly mutated genes encode the chromatin regulators PBRM1, SETD2, and BAP1. How these mutations alter the ch...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-MTAB-1936 | biostudies-arrayexpress
MetabolomicsA female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite
ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human malaria parasite, Plasmodium falciparum, encodes multiple members of this family, one of which, gABCG2, is transcribed predominantly in the gametoc...
2016-09-14 | MTBLS98 | MetaboLights
ProteomicsHs_C-HPP_DentalPulpTails_N-terminomics
Hs_C-HPP, dental pulp proteome, TAILS technique
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005343 | PeptideAtlas
TranscriptomicsTranscription profiling of various types of murine cerebellum cells to investigate the pre-neoplastic stage of medulloblastoma
SUMMARY; Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from transformation of granule cell precursors (GCPs) in the developing cerebellum, but little is known about the early stages of the disease. Here we identify a pre-neoplastic stage of medulloblas...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2426 | biostudies-arrayexpress
GenomicsThe Genomic Binding Sites of an Endogenous Non-Coding RNA
Long non-coding RNAs (lncRNAs) have important regulatory roles and can function at the level of chromatin. To determine where lncRNAs bind to chromatin, we developed CHART, a hybridization-based technique that specifically enriches endogenous RNAs along with their targets from reversibly-crosslinked...
ORGANISM(S): Drosophila melanogaster 
2011-12-07 | E-GEOD-28180 | biostudies-arrayexpress
UnknownEarly Relapse of Follicular Lymphoma After Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Defines Patients at High Risk for Death: An Analysis From the National LymphoCare Study.
Not available
S-EPMC4879714 | biostudies-literature
TranscriptomicsE. coli Anaerobic/aerobic transitions in chemostat
Gene-expression measurements were made over a 20 minute time course as steady state E. coli cells were subjected to an anaerobic to aerobic or an aerobic to anaerobic environmental change.
ORGANISM(S): Escherichia coli 
2012-07-17 | E-MTAB-996 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of synthetic allopolyploid mature flower comparison in Senecio cambrensis
Not available
ORGANISM(S): Senecio cambrensis 
2006-09-19 | E-MAXD-5 | biostudies-arrayexpress
TranscriptomicsProbing Xist RNA structure in cells using Targeted Structure-Seq
The long non-coding RNA (lncRNA) Xist is a master regulator of X-chromosome inactivation in mammalian cells. Models for how Xist and other lncRNAs function depend on thermodynamically stable secondary and higher-order structures that RNAs can form in the context of a cell. Probing accessible RNA bas...
ORGANISM(S): Mus musculus 
2016-02-09 | E-GEOD-67667 | biostudies-arrayexpress
GenomicsThe long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites
Long noncoding RNAs (lncRNAs) are important regulators of chromatin; however, the mechanistic roles for many lncRNAs are poorly understood in part because their direct interactions with genomic loci and proteins are difficult to assess. We used CHART-seq to map the genomic binding sites for two high...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-58444 | biostudies-arrayexpress
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