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MetabolomicsDelayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur in parallel; ...
2024-10-24 | MTBLS7919 | MetaboLights
TranscriptomicsRNA-seq of 36 individuals with autism spectrum disorder
To assess the clinical impact of splice-altering noncoding mutations in autism spectrum disorder (ASD), we used a deep learning framework (SpliceAI) to predict the splice-altering potential of de novo mutations in 3,953 individuals with ASD from the Simons Simplex Collection. To validate these predi...
ORGANISM(S): Homo sapiens 
2018-11-25 | E-MTAB-7351 | biostudies-arrayexpress
UnknownA genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?
Not available
S-EPMC4379124 | biostudies-literature
TranscriptomicsSingle cell transcriptomic of ex vivo-generated lymphoid progenitors from mobilised peripheral blood- or corb blood-derived hematopoietic stem and progenitors cells
We previously established a feeder-free cell therapy platform for the ex vivo generation of lymphoid-primed progenitors using immobilized Delta-like ligand 4 (DLL4), and hereafter known as ProTcell. We demonstrated these progenitors can be generated from hematopoietic stem and progenitors cells orig...
ORGANISM(S): Homo sapiens 
2025-07-23 | GSE292844 | GEO
UnknownEGFR inhibition induces proinflammatory cytokines via NOX4 in HNSCC.
Not available
S-EPMC3869882 | biostudies-literature
UnknownMyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells.
Not available
S-EPMC4401635 | biostudies-literature
UnknownAvailability of Services and Caregiver Burden: Supporting Individuals With Neurogenetic Conditions During the COVID-19 Pandemic.
Not available
S-EPMC8033176 | biostudies-literature
UnknownSPARK: A US Cohort of 50,000 Families to Accelerate Autism Research.
Not available
S-EPMC7444276 | biostudies-literature
UnknownCryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria.
Not available
S-EPMC7263364 | biostudies-literature
TranscriptomicsSingle-cell RNA-seq of intestinal crypts of Red2Kras and Red2Pi3k mice
We isolated mutant and wild-type epithelial cells as well as mesenchymal and immune cells from Confetti, R2Kras and R2Pi3k lines at 2 weeks post-induction and generated single-cell RNA-seq data from them.
ORGANISM(S): Mus musculus 
2021-04-04 | E-MTAB-8656 | biostudies-arrayexpress
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