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TranscriptomicsHuman 32 MPSS samples
This series represents a very deep survey of all transcripts expressed in a wide range of human tissues and cells by Massively Parallel Signature Sequencing (MPSS). These datasets have been generated and donated to the scientific community by Lynx Therapeutics, Inc in Hayward, CA. The data contained...
ORGANISM(S): Homo sapiens 
2005-11-29 | GSE1747 | GEO
TranscriptomicsThe gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons
A challenge in systems biology is to understand the gene regulatory networks that connect early cellular specification to terminal differentiation of specific cell types. In neurogenesis, neural specification has been well studied, but the link between the proneural transcriptional regulators of spe...
ORGANISM(S): Drosophila melanogaster 
2011-02-18 | E-GEOD-21520 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ES cells knocked out for SOCS3
Series contains four arrays - two wildtype, two null. The experiment studied the effect of knocking out SOCS3 in mouse ES cells.
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-2202 | biostudies-arrayexpress
UnknownDerivatization with 2-hydrazino-1-methylpyridine enhances sensitivity of analysis of 5α-dihydrotestosterone in human plasma by liquid chromatography tandem mass spectrometry.
Not available
S-EPMC7938423 | biostudies-literature
UnknownProof of concept for a superior therapeutic index of corticosterone compared with hydrocortisone in patients with congenital adrenal hyperplasia.
Not available
S-EPMC11606648 | biostudies-literature
ProteomicsPharmacological inhibition of the glucocorticoid regenerating enzyme 11ßhydroxysteroid dehydrogenase type 1 after myocardial infarction preserves cardiac function in a translational pig model
Background and Purpose: Adrenal glucocorticoids (GC) increase acutely after myocardial infarction (MI) and thereafter tissue levels are maintained selectively within cells expressing the enzyme 11ßHydroxysteroid Dehydrogenase type 1 (11ßHSD1) that regenerates active GC from circulating metabolites. ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-01-15 | PXD055401 | Pride
Heart Pig 
UnknownLuteal phase oral dexamethasone administration alters endometrial steroid milieu.
Not available
S-EPMC12007876 | biostudies-literature
ProteomicsComplement C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.
Critical illness is characterised by organ failure, dysregulated immune activation and frequent secondary infections. Unbridled complement activation in these patients exposes immune cells to high levels of the anaphylotoxin, C5a. C5a suppresses antimicrobial functions of key immune cells, in partic...
ORGANISM(S): Homo sapiens (Human) 
2020-08-06 | PXD017092 | Pride
Critical care Neutrophils Staphylococcus aureus Complement system proteins Phosphoproteome 
GenomicsA comprehensive assessment of somatic mutation detection in cancer using whole genome sequencing
As whole genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Using tumor-normal sample pairs from two different types of cancer, chronic lymphocytic leukemia and medulloblastoma, we conducted a ...
EGAS00001001539 | EGA
UnknownInjury primes mutation-bearing astrocytes for dedifferentiation in later life.
Not available
S-EPMC10615847 | biostudies-literature
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