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TranscriptomicsMolecular changes in lobular breast cancers in response to endocrine therapy
Invasive lobular cancer (ILC) accounts for approximately 10-15% of breast carcinomas and although it responds poorly to neoadjuvant chemotherapy, it appears to respond well to endocrine therapy. Pre- and on-treatment (after 2 weeks and 3 months) biopsies and surgical samples were obtained from 14 ...
ORGANISM(S): Homo sapiens 
2014-08-11 | E-GEOD-55374 | biostudies-arrayexpress
TranscriptomicsAccurate prediction and validation of response to endocrine therapy in breast cancer
Purpose Aromatase inhibitors (AIs) have an established role in breast cancer treatment. Response rates are only 50-70% in the neoadjuvant setting and lower in advanced disease. Accurate biomarkers are urgently needed to predict response in these settings and to determine which individuals will bene...
ORGANISM(S): Homo sapiens 
2015-07-06 | E-GEOD-59515 | biostudies-arrayexpress
ProteomicsMolecular changes during extended endocrine treatment of breast cancer
Sequential patient-matched samples treated with extended neoadjuvant therapy were studied. Samples were classified as pre-treatment (timepoint1, <0 days), early-on treatment (timepoint2, 0-120 days) and long-term treatment (timepoint4, >120 days).
ORGANISM(S): Homo sapiens (Human) 
2019-02-27 | PXD009328 | Pride
Letrozole Dormancy Sequential samples Breast cancer 
TranscriptomicsDynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer
Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with ER-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may well be expressed in a dynamic manner. In this study we assessed ge...
ORGANISM(S): Homo sapiens 
2010-06-17 | E-GEOD-22386 | biostudies-arrayexpress
UnknownEvaluating body composition in infancy and childhood: A comparison between 4C, QMR, DXA, and ADP.
Not available
S-EPMC7323309 | biostudies-literature
UnknownScoring systems of metabolic syndrome and prediction of cardiovascular events: A population based cohort study.
Not available
S-EPMC9175260 | biostudies-literature
TranscriptomicsAnalysis of Promoter Methylation in Breast Cancer
Promoter methylation was assayed in a number of breast cancer and control normal samples along with the effects of 5'-aza-2'-deoxycytidine on breast cancer cell line transcriptomes. Aberrant promoter hypermethylation is frequently observed in cancer. The potential for this to contribute to tumour d...
ORGANISM(S): Homo sapiens 
2011-03-07 | E-GEOD-26990 | biostudies-arrayexpress
UnknownDecreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.
Not available
S-EPMC3937431 | biostudies-literature
TranscriptomicsTumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies II
Background: Gene expression profiling has been used extensively within breast cancer research. Patient matched transcriptomic studies of tumour samples before and after treatment offer great potential and have been initiated, but tend not to include a control group. Here we examine gene expression c...
ORGANISM(S): Homo sapiens 
2016-08-08 | E-GEOD-76727 | biostudies-arrayexpress
UnknownNuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.
Not available
S-EPMC6126615 | biostudies-literature
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