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MetabolomicsSIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux
Mitochondrial function relies on the coordinated transcription of mitochondrial and nuclear genomes to assemble respiratory chain complexes. Across species, the SIN3 coregulator influences mitochondrial functions, but how its loss impacts mitochondrial homeostasis and metabolism in the context of a ...
2024-04-01 | MTBLS8439 | MetaboLights
ProteomicsMS-based proteomic characterization of SIN3-containing complexes in C. elegans
The SIN3 transcriptional coregulator influences gene expression through multiple interactions that include histone deacetylases (HDACs). Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intellectual disability (ID)/autism syndromes, emphasizing...
ORGANISM(S): Caenorhabditis elegans 
2023-10-02 | PXD039853 | Pride
Caenorhabditis elegans Co-immunoprecipitation Sin3 transcriptional coregulator Nanolc-ms/ms 
UnknownSIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux.
Not available
S-EPMC11091686 | biostudies-literature
GenomicsSIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans [sin-3(tm1276)]
SIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans [sin-3(tm1276)]
PRJNA945400 | ENA
TranscriptomicsSIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans [sin-3(tm1276)]
The SIN3 transcriptional coregulator influences gene expression through multiple interactions that include histone deacetylases (HDACs). Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intellectual disability (ID)/autism syndromes, emphasizing...
ORGANISM(S): Caenorhabditis elegans 
2023-10-04 | GSE227498 | GEO
TranscriptomicsSIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans [sin-3(syb2172) and hda-3(ok1991)]
The SIN3 transcriptional coregulator influences gene expression through multiple interactions that include histone deacetylases (HDACs). Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intellectual disability (ID)/autism syndromes, emphasizing...
ORGANISM(S): Caenorhabditis elegans 
2023-10-04 | GSE227368 | GEO
GenomicsSIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans [sin-3(syb2172) and hda-3(ok1991)]
SIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans [sin-3(syb2172) and hda-3(ok1991)]
PRJNA944713 | ENA
UnknownConserved themes in target recognition by the PAH1 and PAH2 domains of the Sin3 transcriptional corepressor.
Not available
S-EPMC2259223 | biostudies-literature
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