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Proteomicsc-Abl Dependent Tyrosine Phosphorylation of theCo-chaperone Aha1 Regulates Interaction with Hsp90
The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity tailoring the chaperone function to specific “client” proteins. The intracellular signaling mechanisms directly regulating Aha1 association wi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080713 | MassIVE
TranscriptomicsTranscriptome profiling of T84 colorectal carcinoma cells treated with receptor guanylyl cyclace C agonist (stable toxin)
Receptor guanylyl cyclase C (GC-C) is expressed in the intestinal epithelia and plays a key role in intestinal physiology. Activation of GC-C by its ligands has been shown to regulate proliferation and differentiation of enterocytes along the crypt-villus axis. This study aims to identify genes regu...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-45531 | biostudies-arrayexpress
TranscriptomicsDifferential production of Type I IFN determines the reciprocal levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages
Pattern recognition receptors (PRR) detect microbial products and induce cytokines which shape the immunological response. Interleukin-12 (IL-12), tumor necrosis factor alpha (TNF-α) and IL-1β are proinflammatory cytokines which can be essential for resistance against infection, but if produced at...
ORGANISM(S): Mus musculus 
2016-09-07 | E-GEOD-79809 | biostudies-arrayexpress
TranscriptomicsConserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response
Discriminating pathogenic bacteria from energy-harvesting commensals is key to host immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the role of this nutrient-sensing pathway in the Caenorhabidits elegans innate immune response. Using w...
ORGANISM(S): Caenorhabditis elegans 
2015-05-01 | E-GEOD-53732 | biostudies-arrayexpress
TranscriptomicsPRPF8 CLIP seq for iPSC, kidney organoid, retinal organoid, and retinal epithelium derived from c.6926A>C RPE with Retinitis Pigmentosa patients and CRISPR/Cas9 corrected
Retinitis Pigmentosa is a group of inherited eye disorders characterized by progressive degeneration of photoreceptor cells in the retina, leading to vision loss and eventual blindness. One of the known genetic mutations associated with RP is the c.6926A>C mutation in the RPE (retinal pigment epithe...
ORGANISM(S): Homo sapiens 
2024-03-13 | E-MTAB-13171 | biostudies-arrayexpress
TranscriptomicsAberrant DNA methylation in hepatitis B and C virus-related hepatocellular carcinoma
Chronic infections by hepatitis B virus (HBV) and hepatitis C virus (HCV) appear to be the most significant causes of hepatocellular carcinoma (HCC). Aberrant promoter methylation is known to be deeply involved in cancer, including HCC. In this study, we analyzed aberrant promoter methylation on gen...
ORGANISM(S): Homo sapiens 
2010-07-06 | E-GEOD-19665 | biostudies-arrayexpress
UnknownIn silico analysis of the Seven IN Absentia (SINA) genes in bread wheat sheds light on their structure in plants.
Not available
S-EPMC10734943 | biostudies-literature
UnknownMagnetization of graphene oxide nanosheets using nickel magnetic nanoparticles as a novel support for the fabrication of copper as a practical, selective, and reusable nanocatalyst in C-C and C-O coupling reactions.
Not available
S-EPMC9037157 | biostudies-literature
TranscriptomicsTranscription profiling of mouse embryonic day 13.5 and 15.5 fetal livers lacking p38alpha, a mitogen-activated kinase that controls inflammatory responses and cell proliferation
The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation. Using mice carrying conditional p38alpha alleles, we investigated its function in postnatal development and tumorigenesis. When p38alpha is specifically deleted in the mouse embryo, fetuses d...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7342 | biostudies-arrayexpress
TranscriptomicsCCAAT/Enhancer Binding Proteins (C/EBP)-M-NM-1 and -M-NM-2 are Essential for Ovulation, Luteinization and the Expression of Key Target Genes
Luteinizing hormone (LH) activation of the EGF receptor/RAS/ERK1/2 pathway is essential for ovulation and luteinization because granulosa cell depletion of Erk1/2 (Erk1/2gc-/- mice) renders mice completely infertile. Because of their potential as mediators of ERK1/2-dependent granulosa cell differe...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-23084 | biostudies-arrayexpress
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