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TranscriptomicsExpression profiling of BRAFV600E melanoma cell lines upon RAF inhibition
Microarray expression analysis to identify global changes in transcription in response to RAF inhibition. Genes under RAF control were identified in a panel of BRAFV600E tumor cells, following the short-term inhibition of RAF using a pan-RAF kinase inhibitor, PLX4032 (Plexxikon). For comparison with...
ORGANISM(S): Homo sapiens 
2010-07-18 | E-GEOD-20051 | biostudies-arrayexpress
ProteomicsS.cerevisiae - Whole organism, Intensity of gfp-tagged proteins, YEPD normalized data (Newman,nature,2006)
abundance based on YEPD normalized data, intensity of GFP-tagged proteins, Interaction consistency score: 8.2, Coverage: 38
ORGANISM(S): 4932 
2006-00-00 | 1367210792 | PAXDB
ProteomicsS.cerevisiae - Whole organism, Intensity of gfp-tagged proteins, SD normalized data (Newman,nature,2006)
abundance based on SD normalized data, intensity of GFP-tagged proteins, Interaction consistency score: 7.5, Coverage: 37
ORGANISM(S): 4932 
2006-00-00 | 3388877431 | PAXDB
TranscriptomicsTranscription profiling of human primary human macrophages over the course of HIV-1 infection reveals HIV-1 activates macrophages independent of Toll-like receptors
Macrophages provide an interface between innate and adaptive immunity and are important long-lived reservoirs for Human Immunodeficiency Virus Type-1 (HIV-1). Multiple genetic networks involved in regulating signal transduction cascades and immune responses in macrophages are coordinately modulated ...
ORGANISM(S): Homo sapiens 
2009-01-15 | E-GEOD-13395 | biostudies-arrayexpress
TranscriptomicsThe Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus
Pre-mRNA splicing is regulated by developmental and environmental cues, but little is known about how specific signals are transduced in mammalian cells to regulate this critical gene expression step. Here, we report massive reprogramming of alternative splicing in response to EGF signaling. By blo...
ORGANISM(S): Homo sapiens 
2012-08-17 | E-GEOD-37731 | biostudies-arrayexpress
TranscriptomicsPlatform comparison and transcription profiling of mixed tissue RNA samples formulated to contain different ratios of RNA for each of four rat tissues (brain, liver, kidney, and testes) on Affymetrix RAE230A, CodeLink UniSet Rat I, and Agilent G4130A rat oligonucleotide arrays
This experiment is a test of a reagent that can provide a basis for performance assessments on Affymetrix RAE230A, CodeLink UniSet Rat I, and Agilent G4130A rat oligonucleotide arrays. The reagent is a set of two mixed tissue RNA samples formulated to contain different ratios of RNA for each of f...
ORGANISM(S): Rattus norvegicus 
2010-03-30 | E-TABM-16 | biostudies-arrayexpress
ProteomicsCharacterization of signaling pathways associated with pancreatic β-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice
Obesity-linked type 2 diabetes (T2D) is a major health problem of global epidemic proportions. The onset of T2D is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to o...
ORGANISM(S): Mus Musculus 
2020-05-18 | PXD016392 | panorama
ProteomicsMeant_RSK_BioID_2019
This dataset consists of 33 raw MS files and associated peak lists and result files, acquired on an Orbitrap Fusion Tribrid mass spectrometer operated in Data Dependent Acquisition mode. The files are associated with a manuscript submitted for publication by Antoine Meant et al. titled: RSK promote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-02-07 | MSV000083414 | MassIVE
TranscriptomicsPRPF8 CLIP seq for iPSC, kidney organoid, retinal organoid, and retinal epithelium derived from c.6926A>C RPE with Retinitis Pigmentosa patients and CRISPR/Cas9 corrected
Retinitis Pigmentosa is a group of inherited eye disorders characterized by progressive degeneration of photoreceptor cells in the retina, leading to vision loss and eventual blindness. One of the known genetic mutations associated with RP is the c.6926A>C mutation in the RPE (retinal pigment epithe...
ORGANISM(S): Homo sapiens 
2024-03-13 | E-MTAB-13171 | biostudies-arrayexpress
UnknownNormative Data and Conversion Equation for Spectral-Domain Optical Coherence Tomography in an International Healthy Control Cohort.
Not available
S-EPMC10350791 | biostudies-literature
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