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UnknownProbing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors.
Not available
S-EPMC8458670 | biostudies-literature
UnknownDevelopment of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase.
Not available
S-EPMC5431627 | biostudies-literature
UnknownA randomized pilot study of the prophylactic effect of ketamine on laboratory-induced stress in healthy adults.
Not available
S-EPMC9813787 | biostudies-literature
ProteomicsS-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver
MCJ (Methylation-Controlled J protein), an endogenous repressor of the mitochondrial respiratory chain, is upregulated in multiple liver diseases but little is known about how it is regulated. S-adenosylmethionine (SAMe), the biological methyl donor, is frequently depleted in chronic liver diseases....
ORGANISM(S): Mus Musculus 
PXD042309 | panorama
ProteomicsS-Adenosylmethionine Depletion Activates La Ribonucleoprotein Domain Family Member 1 to Induce Protein Translation
S-adenosylmethionine (SAMe) is the principal methyl donor synthesized by methionine adenosyltransferase 1A (MAT1A)-encoded enzyme in the liver. Mice lacking Mat1a have hepatic SAMe depletion, spontaneous development of non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). To under...
ORGANISM(S): Homo Sapiens Mus Musculus 
2020-06-26 | PXD020015 | panorama
UnknownStructures of NS5 Methyltransferase from Zika Virus.
Not available
S-EPMC5074680 | biostudies-literature
UnknownStructures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
Not available
S-EPMC10414583 | biostudies-literature
GenomicsATRX tolerates activity-dependent histone H3 M-bM-^@M-^\methyl/phos switchingM-bM-^@M-^] to maintain repetitive element silencing in neurons
ATRX is a member of the SWI2/SNF2 family of chromatin remodeling proteins and primarily functions at heterochromatic loci via its recognition of M-bM-^@M-^XrepressiveM-bM-^@M-^Y histone modifications (e.g., H3K9me3). Despite significant roles for ATRX during normal neural development, as well as its...
ORGANISM(S): Mus musculus 
2015-01-02 | E-GEOD-64062 | biostudies-arrayexpress
UnknownStructure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activity.
Not available
S-EPMC3326379 | biostudies-literature
UnknownHigh resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development.
Not available
S-EPMC8923114 | biostudies-literature
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