A randomized pilot study of the prophylactic effect of ketamine on laboratory-induced stress in healthy adults.

ABSTRACT:

Background

Stress exposure is a key risk factor for the development of major depressive disorder and posttraumatic stress disorder. Enhancing stress resilience in at-risk populations could potentially protect against stress-induced disorders. The administration of ketamine one week prior to an acute stressor prevents the development of stress-induced depressive-like behavior in rodents. This study aimed to test if the prophylactic effect of ketamine against stress also applies to humans.

Methods

We conducted a double-blind, placebo-controlled study wherein 24 healthy subjects (n = 11 males) were randomized to receive either ketamine (0.5 mg/kg) or midazolam (0.045 mg/kg) intravenously one week prior to an acute stress [Trier Social Stress Test (TSST)]. The primary endpoint w

SUBMITTER: Costi S 

PROVIDER: S-EPMC9813787 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature