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ModelsSingh2006_IL6_Signal_Transduction
The model reproduces Fig 2 , Fig3A and Fig 3B of the paper. The ODE for x1(gp180) and x3 (gp 130) is wrong and the authors have communicated to the curator that the species ought to have a constant value. There are a few other differences from the paper and these were made in consultation with the ...
2024-09-02 | BIOMD0000000151 | BioModels
ProteomicsMetalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Removal
Cytotoxicity of DNA-protein crosslinks (DPCs) is ascribed largely to their ability to block the progression of DNA replication fork. DPCs are frequently occurring in cells, either as a consequence of metabolism or exogenous agents. The mechanism of DPCs removal is not completely understood. Here, we...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080743 | MassIVE
TranscriptomicsA systematic search for transgenerational effect of drug exposure to adult males using a novel Drosophila model
Drosophila melanogaster adult flies fed on food containing 16 mg/ml of pentylenetetrazole (PTZ) in the food show a hyperkinetic behavior within 24 hours. Half of that concentration, i.e., 8 mg/ml, of PTZ, if fed for seven days, though doesn’t cause seizure-like behavior, results in a decreased climb...
ORGANISM(S): Drosophila melanogaster 
2009-03-25 | E-GEOD-15136 | biostudies-arrayexpress
TranscriptomicsChronic Pentylenetetrazol treatment induced successive gene expression changes in Drosophila head
Pentylenetetrazol (PTZ)-induced kindling in rodents is an established model of epileptogenesis. The molecular basis of the associated long-term plasticity is however not clear. Further, rodent models of kindling plasticity are not amenable to large-scale screening of compounds for identifying antiep...
ORGANISM(S): Drosophila melanogaster 
2007-10-01 | E-GEOD-7120 | biostudies-arrayexpress
TranscriptomicsControl cDNA microarray profiles of Drosophila head
In the process of developing a biological systems model of kindling-like plasticity in the fruit fly, we performed a control gene expression profiling analysis in which RNA isolated from different pools of heads of wild-type flies grown on normal food (NF) were compared between themselves using cDNA...
ORGANISM(S): Drosophila melanogaster 
2007-10-01 | E-GEOD-7037 | biostudies-arrayexpress
ProteomicsSynechocystis.sp. 6803 - Whole organism, SC (Wegener,mcp,2010)
abundance based on Spectral counting, Interaction consistency score: 6.1, Coverage: 38
ORGANISM(S): 1148 
2010-00-00 | 1305834575 | PAXDB
TranscriptomicsChronic Pentylenetetrazol withdrawal induced successive gene expression changes in Drosophila head
Kindling induced by Pentylenetetrazol is an established rodent model of epileptogenesis. The molecular basis of the long-term plasticity involved is however not clear. In addition, rodent models of kindling plasticity are not useful for large-scale screening of compounds to identify antiepileptogeni...
ORGANISM(S): Drosophila melanogaster 
2007-10-01 | E-GEOD-7156 | biostudies-arrayexpress
TranscriptomicsChronic tetraethylammonium chloride treatment induced gene expression changes in Drosophila head
Tetraethylammonium chloride (TEA) is an epileptogenic agent. In an effort to develop a Drosophila model of kindling epileptogenesis, we have examined chronic TEA induced alterations in gene expression profile of fly heads. Expression profiling of fly heads after 7 day long TEA treatment revealed per...
ORGANISM(S): Drosophila melanogaster 
2010-05-25 | E-GEOD-7783 | biostudies-arrayexpress
TranscriptomicsChronic pilocarpine hydrochloride treatment induced gene expression changes in Drosophila head
Pilocarpine hydrochloride (PILO) is an epileptogenic agent. In an effort to develop a Drosophila model of kindling epileptogenesis, we have examined chronic PILO induced alterations in gene expression profile of fly heads. Expression profiling of fly heads after 7 day long PILO treatment revealed pe...
ORGANISM(S): Drosophila melanogaster 
2010-05-25 | E-GEOD-7787 | biostudies-arrayexpress
TranscriptomicsEffect of vigabatrin on gene expression in Drosophila head
We recently developed a fly model of pentylenetetrazol (PTZ)-induced long-term behavioral plasticity. Pharmacological validation suggests this model to be kindling-like. Hence, our model is of relevance in understanding the molecular pathogenesis of epileptogenesis as well as in screening potential ...
ORGANISM(S): Drosophila melanogaster 
2007-10-04 | E-GEOD-7203 | biostudies-arrayexpress
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