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TranscriptomicsGene expression in human fungal pathogen Coccidioides immitis changes as mycelia differentiate into spherules and mature
Coccidioides immitis (C. immitis) is a dimorphic fungus that causes disease in mammals including human beings. It grows as a mycelium in the soil but differentiates into a pathogenic structure called a spherule in the host. We compared the transcriptome of C. immitis mycelia and day 2 and day 8 sphe...
ORGANISM(S): Coccidioides immitis RS 
2013-07-11 | E-GEOD-44225 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression in HIV-Infected Individuals Following ART.
A paired analysis of peripheral blood mononuclear cells (PBMCs) isolated before and after antiretroviral therapy (ART) from a robust number of HIV-infected patients (N=36). Results identify a total of 4,157 DEGs following ART in HIV-infected participants and the transition from a period of active vi...
ORGANISM(S): Homo sapiens 
2013-09-10 | E-GEOD-44228 | biostudies-arrayexpress
TranscriptomicsHIV downregulates interferon stimulated genes in primary macrophages.
HIV is able to outpace the innate immune response, including the response mediated by interferon (IFN), to establish a productive infection. However, monocyte derived macrophages (MDMs) may be protected from HIV infection by treatment with type I IFN before virus exposure. The ability of HIV to mo...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-41731 | biostudies-arrayexpress
TranscriptomicsFactors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection.
Mouse strains have been identified that are resistant (i.e. DBA/2) or susceptible (i.e. C57BL/6) to infection from pathogenic fungus Coccidioides immitis. However, the genetic and immunological basis for this difference has not been fully characterized. Microarray technology was used to identify ge...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-40379 | biostudies-arrayexpress
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