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TranscriptomicsChip-chip of Sir3 and of Sir2, and ChAP-chip of AAR from budding yeast cells
O-acetyl-ADP-ribose (AAR) is a small metabolic molecule that is generated during NAD-dependent deacetylation by Sir2. Sir2 regulates gene expression, DNA repair, and genome stability. chromatin affinity-precipitation (ChAP) method was used to detect the chromatin fragments at which small molecules i...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-31 | E-GEOD-65672 | biostudies-arrayexpress
TranscriptomicsRap1, Sir2, Sir3, Sir4 immunoprecipitations
All Rap1, Sir2, Sir3, Sir4, and mock immunoprecipitation experiments associated with Lieb et al. Nature Genetics, August 2001, Volume 28, Issue 4 Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Computed
ORGANISM(S): Saccharomyces cerevisiae 
2005-09-24 | E-GEOD-3360 | biostudies-arrayexpress
TranscriptomicsSIRT1 and H1AcK26 promoter-association in mouse ES cells changes upon oxidative stress
Association of the (histone) deacetylase SIRT1 with promoters was assessed to determine putative SIRT1-regulated genes. Based on the observation that the SIRT1 yeast ortholog Sir2 redistributes across the yeast genome in repsonse to genotoxic stress and double strand breaks (DSBs), we investigated t...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-13075 | biostudies-arrayexpress
GenomicsSir2 recruitment after synchronization
Sir2 recruitment after synchronization
PRJNA923803 | ENA
TranscriptomicsSir2 mutants versus Controls at 2 weeks of age
Although SIRT1 plays a central role in maintaining metabolic homeostasis, the molecular mechanisms remain unclear. Here we show that loss of the Drosophila SIRT1 homolog sir2 leads to the progressive onset of diabetic phenotypes, similar to studies of SIRT1 in mice. Sir2 function is both necessary a...
ORGANISM(S): Drosophila melanogaster 
2016-02-29 | E-GEOD-72947 | biostudies-arrayexpress
GenomicsMNase-seq of sir2 in Saccharomyces cerevisiae
MNase-seq of sir2 in Saccharomyces cerevisiae
PRJNA802810 | ENA
TranscriptomicsGene Expression Analysis of Fat Body of Drosophila melanogaster Subjected to Sir2 Overexpression or Dietary Restriction
Sir2 is the most intensively discussed longevity gene in current aging research. Although the gene encoding for a NAD+-dependent histone deacetylase initially was found to extend lifespan of various organisms ranging from yeast to mammals, serious doubts regarding its role in longevity have been exp...
ORGANISM(S): Drosophila melanogaster 
2013-05-01 | E-GEOD-45974 | biostudies-arrayexpress
TranscriptomicsYeast expression data from conditions that inhibit sirtuins
Sir2 is an NAD+-dependent histone deacetylase, and is the founding member of a large, phylogentically conserved, family of such deacetylases called the Sirtuins. The budding yeast, Saccharomyces cerevisiae, harbors 4 paralogs of Sir2, known as Hst1, Hst2, Hst3, and Hst4. Reducing the intracellular N...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-10 | E-GEOD-18488 | biostudies-arrayexpress
TranscriptomicsThe transcriptomic changes affected by BDF2 and SIR2 under salt stress
The strain bdf1M-bM-^HM-^Fbdf2M-bM-^HM-^F[BDF2 L][SIR2 H] improved salt resistance of bdf1M-bM-^HM-^F. To gain further insight into the mechanism of BDF1 in suppressing bdf1M-bM-^HM-^F salt sensitivity, DNA microarray analysis was performed to determine the reason for the salt sensitivity of bdf1M-b...
ORGANISM(S): Saccharomyces cerevisiae 
2014-05-26 | E-GEOD-47367 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of yeast using Sir2 in Lieb et al 2001
All Sir2 immunoprecipitation experiments associated with Lieb et al. Nature Genetics, August 2001, Volume 28, Issue 4
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-30 | E-SMDB-605 | biostudies-arrayexpress
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