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MetabolomicsSIRT3-dependent glutaminolysis enhances germinal center epigenetic programming through α-ketoglutarate

Germinal center (GC) B cells depend on sustained epigenetic modulation to maintain transcriptional identity and support affinity maturation; however, whether mitochondrial metabolism directly enhances this chromatin state remains unclear. Here, we show that enhanced SIRT3 activity promotes glutam...

2026-09-04 | MTBLS15385 | MetaboLights
MetabolomicsSIRT5 alleviate cardiomyocyte senescence in radiation-induced heart disease via desuccinylation of HADHB

SIRT5 deficiency caused widespread protein hypersuccinylation in cardiac tissue. Succinylation proteomic analysis revealed HADHB as the key SIRT5 target, with lysine 292 (K292) being the dominant succinylation site. Functional studies demonstrated that K292 succinylation impairs HADHB-mediated fa...

2026-03-15 | MTBLS14057 | MetaboLights
MetabolomicsMetabolomics analysis of Sirt5 knockdown (KD) melanoma
Not available
ORGANISM(S): Homo sapiens 
ST000698 | MetabolomicsWorkbench
MetabolomicsLiver metabolomics in old liver-specific SIRT6 overexpressing mice
Not available
ORGANISM(S): Mus musculus 
ST001508 | MetabolomicsWorkbench
MetabolomicsTargeting Sirt2 reprograms T cell metabolism for effective immune response
Not available
ORGANISM(S): Mus musculus 
ST001373 | MetabolomicsWorkbench
MetabolomicsMetabolomics analysis of mouse liver with or without SIRT5 deficiency
Not available
ORGANISM(S): Mus musculus 
ST002152 | MetabolomicsWorkbench
MetabolomicsL-serine enables reducing the virulence of Acinetobacter baumannii and modulating the SIRT1 pathway to eliminate the pathogen

The emergence of high-virulent Acinetobacter baumannii strains increases the mortality of patients and seriously affects their prognosis, which motivates us to explore novel ways to control such infections. In this study, gas chromatography-mass spectrometry was adopted to explore the me...

2024-01-18 | MTBLS8966 | MetaboLights
MetabolomicsDendrobium officinale Polysaccharide Ameliorates High-Fat Diet-Induced Hepatic Lipid Metabolic Disorder via the SIRT6/PGC-1α Signaling Axis
Aims: This study aims to explore the potential therapeutic effect of Dendrobium officinale polysaccharide (DOP) on non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD), and to elucidate the underlying mechanism involving the SIRT6/PGC-1α signaling axis and the regulation of the g...
2026-05-25 | MTBLS14575 | MetaboLights
MetabolomicsGenetic and metabolic characterization of bioengineered human fatty liver tissue with modified SIRT1 expression
Not available
ORGANISM(S): Homo sapiens 
ST001185 | MetabolomicsWorkbench
MetabolomicsHepatic [U-13C]Lactate tracing and metabolomics in young and old WT and SIRT6 overexpressing mice
Not available
ORGANISM(S): Mus musculus 
ST001507 | MetabolomicsWorkbench
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