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ProteomicsDiscovery of an ApoE4-Targeted Small-Molecule SirT1 Enhancer for the Treatment of Alzheimer’s Disease
Herein we describe the discovery of an orally brain-22 permeable small-molecule, DDL-218, that enhanced SirT1 in ApoE4-expressing neuronal cells 23 and a murine AD model. DDL-218 increased the transcription factor NFYb resulting in 24 upregulation of PRMT5. Mechanistic and modeling studies show that...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD060379 | Pride
Sirtuin 1 Prmt5 Nfyb Sirt1 Sirt1 enhancer Memory Apolipoprotein e4 
UnknownSIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity.
Not available
S-EPMC5756502 | biostudies-literature
TranscriptomicsHistone/Protein Deacetylase-6, -9, and Sirtuin-1 Control Foxp3+ Treg Through Shared and Isotype-Specific Mechanisms
Targeting histone/protein deacetylase (HDAC)-6, -9, or Sirtuin-1 (Sirt1) augments the suppressive functions of Foxp3+ T regulatory (Treg) cells, but it is unclear if this involves different mechanisms, such that combined inhibition would be beneficial. We compared the suppressive functions of Tregs ...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36095 | biostudies-arrayexpress
UnknownMyocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway.
Not available
S-EPMC6594820 | biostudies-literature
UnknownPan-cancer analysis of super-enhancer-induced LINC00862 and validation as a SIRT1-promoting factor in cervical cancer and gastric cancer.
Not available
S-EPMC11097084 | biostudies-literature
TranscriptomicsSirt1 targeting promotes Treg function
Sirtuin-1 (Sirt1), a class III histone/protein deacetylase is central to cellular metabolism, stress responses and aging, but its contributions to various host immune functions have been little investigated. To study the role of Sirt1 in T-cell functions, we undertook targeted deletions by mating mi...
ORGANISM(S): Mus musculus 
2011-01-05 | E-GEOD-26425 | biostudies-arrayexpress
UnknownRole of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke.
Not available
S-EPMC6933319 | biostudies-literature
UnknownDiscovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer's disease.
Not available
S-EPMC12019328 | biostudies-literature
UnknownA Therapeutically Targetable NOTCH1-SIRT1-KAT7 Axis in T-cell Leukemia.
Not available
S-EPMC9818047 | biostudies-literature
UnknownSIRT1 activity orchestrates ECM expression during hESC-chondrogenic differentiation.
Not available
S-EPMC9322318 | biostudies-literature
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