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Mitochondrial activity is critical for cellular vitality and organismal longevity, yet underlying regulatory mechanisms spanning these different levels of organization remain elusive. From RNAi screens for mitochondrial biogenesis, we discovered NFYB-1, a subunit of the NF-Y transcriptional complex,...
ORGANISM(S): Caenorhabditis elegans 
2020-03-11 | PXD013233 | Pride
NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin
LncRNA-NFYB axis drives immune suppression to promote HCC progression by a positive feedback
Mitochondrial activity is critical for cellular vitality and organismal longevity, yet underlying regulatory mechanisms spanning these different levels of organization remain elusive. From RNAi screens for mitochondrial biogenesis, we discovered NFYB-1, a subunit of the NF-Y transcriptional complex,...
ORGANISM(S): Caenorhabditis elegans 
2020-03-11 | GSE127917 | GEO
Metastases are the main cause of cancer mortality, but the mechanisms underlying aggressive progression remain poorly understood. Genome-wide characterization of chromatin accessibility reveals the opening of large numbers of distal regulatory elements across the genome during metastatic progression...
ORGANISM(S): Homo sapiens 
2026-07-01 | GSE154509 | GEO
Genomics
iPSC Exosomes Rejuvenate Senescent Basal Stem Cells via YBX1-NFYB Axis
E2F1 induces numerous genes, including transcription factors, upon activation. The transcription factors then further cooperates with E2F1 to regulate the target genes and enhance the transcriptional effect. We used microarrays to analyze genes upregulated upon E2F1 activation by OHT with and withou...
ORGANISM(S): Homo sapiens 
2016-09-09 | GSE61272 | GEO
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