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TranscriptomicsMolecular phenotyping of multiple mouse strains under metabolic challenge uncovers Elovl2 as a novel regulator of glucose-induced insulin secretion
Defective insulin secretion by pancreatic β cells underlies the development of type 2 diabetes (T2D). High fat diet-fed mice are commonly used to study diabetes progression, but studies are usually limited to a single strain, such as C57Bl/6J. Here, we use a systems biology approach to integrate la...
ORGANISM(S): Mus musculus 
2017-04-28 | E-GEOD-78183 | biostudies-arrayexpress
TranscriptomicsMolecular prediction of gastrulation stages with small extra-embryonic gene-set
Axis specification in mouse is determined by a sequence of reciprocal interactions between embryonic and extra-embryonic tissues so that a few extra-embryonic genes appear as ‘patterning’ the embryo. Considering these interactions as essential, but lacking in most mammals the genetically driven appr...
ORGANISM(S): Bos taurus 
2010-06-24 | E-GEOD-13013 | biostudies-arrayexpress
TranscriptomicsEffect of ovarian stimulation on oocyte gene expression in cow
The objective of the study was to analyze the impact of FSH on transcriptome changes of in vivo bovine oocytes. Oocytes were collected from naturally ovulated and superovulated animals at 2 hours pre-LH surge, 6 hours post-LH surge, and 22 hours post-LH surge. Six-condition experiment. Biological re...
ORGANISM(S): Bos taurus 
2011-07-31 | E-GEOD-27696 | biostudies-arrayexpress
TranscriptomicsXenopus M-phase extract treated induced pluripotent stem cells
Transfer of somatic cell nuclei to enucleated eggs or ectopic expression of specific transcription factors are two different reprogramming strategies used to generate pluripotent cells from differentiated cells. However, they are poorly efficient and other unknown factors might be required to increa...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-31691 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide analysis of active xylem in White Spruce and Norway Spruce during the growth season
The goal is to look at changes in the pattern of expression of the xylem transcriptome through the growth season in two spruces (Picea glauca and Picea abies). One-color comparison of active xylem collected in June, July, August and September, in two spruce species. Six biological repetitions per ti...
ORGANISM(S): Picea abies 
2015-01-21 | E-GEOD-51884 | biostudies-arrayexpress
TranscriptomicsEarly disruption of maternal-zygotic interaction and activation of defense-like responses in Arabidopsis interspecific incompatibility
Hybridization of diverged taxa often result in lethality or sterility. We previously described natural variation for postzygotic incompatibility in the cross of diploid Arabidopsis thaliana to Arabidopsis arenosa. Hybrid seed death in this system has a complex genetic basis, involving many non-addit...
ORGANISM(S): Arabidopsis thaliana 
2013-06-05 | E-GEOD-42957 | biostudies-arrayexpress
TranscriptomicsTranscriptional gene silencing mediated by interplay of MOM1 and Pol V
In plants, multiple levels of epigenetic control suppress transposon movement and permit somatic as well as transgenerational transmission of gene expression patterns. A variety of factors are involved that establish and/or maintain epigenetic marks, such as covalent modification of DNA and histones...
ORGANISM(S): Arabidopsis thaliana 
2010-06-19 | E-GEOD-17940 | biostudies-arrayexpress
UnknownRTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.
Not available
S-EPMC4334775 | biostudies-literature
TranscriptomicsMolecular regulation of enhanced muscle mass in developing Blond Aquitaine foetuses compared to Charolais
Background : The Blonde Aquitaine (BA) is a French beef breed with enhanced muscularity of unknown genetic origin. Targeted sequencing has shown that the BA is not a carrier of any of the bovine MSTN mutations. At the protein level the BA shows a transition to a faster muscle isoform phenotype with ...
ORGANISM(S): Bos taurus 
2015-08-01 | E-GEOD-60844 | biostudies-arrayexpress
TranscriptomicsBeta-catenin status in pediatric medulloblastomas
Medulloblastoma is the most frequent malignant pediatric brain tumor. Considerable efforts are dedicated to identify markers that help to refine treatment strategies. The activation of the Wnt/beta-catenin pathway occurs in 10-15% of medulloblastomas and has been recently described as a marker for f...
ORGANISM(S): Homo sapiens 
2009-02-02 | E-GEOD-12992 | biostudies-arrayexpress
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