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TranscriptomicsScreening target genes of miR-100 in MGC-803 and SK-BR-3 cells
We tried to find the target genes of miR-100 in MGC-803 and SK-BR-3 cells, thus we uesd specific miR-100 inhibitor to knock down the level of miR-100 in the cells, with this condition, we used this mRNA microarray to find the genes whose amount changed. and they may be the target genes that miR-100 ...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-53909 | biostudies-arrayexpress
TranscriptomicsCancer associated fibroblasts (CAFs), CD133- (SK-BR-3 and MDA-MB-231 mixed) and CD133+ cells (SK-BR-3 and MDA-MB-231 mixed)
CAFs were indirectly co-cultured with SK-BR-3 or MDA-MB-231 cells (CAFs, ZQY042, Zhongqiao Xinzhou Biotechnology Co., Ltd.) for one week using a 0.4um transwell chamber, after which the CAFs were harvested. FITC anti-human CD133 antibody (W6B3C1, BioLegend) was used to sort CD133- and CD133+ cells...
ORGANISM(S): Homo sapiens 
2025-09-30 | E-MTAB-14538 | biostudies-arrayexpress
ProteomicsLapatinib-Induced Enhancement Of Mitochondrial Respiration In HER2-Positive SK-BR-3 Cells: Mechanism Revealed By Analysis Of Proteomic But Not Transcriptomic Data
Dual inhibitors of HER2 and EGFR, such as lapatinib, have shown significant efficacy for the therapy of HER2-positive breast cancer. Previous experiments showed that in cell cultures, the efficacy of lapatinib was significantly reduced by exposure to human serum and human epidermal growth factor (EG...
ORGANISM(S): Homo sapiens (Human) 
2024-09-26 | PXD054180 | Pride
Proteomics Squamous cell carcinoma sk-br-3 Her-targeted cancer therapy Drug resistance Tricarboxylic acid cycle tca Human blood serum Cellular respiration Lapatinib 
GenomicsRNA sequencing data of SK-BR-3 Parental vs lapatinib resistance (LR) cells
RNA sequencing data of SK-BR-3 Parental vs lapatinib resistance (LR) cells
PRJNA646412 | ENA
TranscriptomicsRNA sequencing data of SK-BR-3 Parental vs lapatinib resistance (LR) cells
Transcriptional profiling of SK-BR-3 lapatinib resistance cells comparing control SK-BR-3 parental cells. Randomly fragmented the purified RNA for sequencing with a short read and reverse-transcrived. Attached different adapters to both end of cDNA and ligated them and amplified. Calculate the amoun...
ORGANISM(S): Homo sapiens 
2022-07-31 | GSE154470 | GEO
TranscriptomicsGenome-wide analysis of GW3965-responsive genes in 4 different breast cancer cell lines, MCF-7, T-47D, SK-BR-3, and MDA-MB-231
Analysis of differentially expressed genes in response to the LXR agonist GW3965 in the MCF-7, T-47D, SK-BR-3, and MDA-MB-231 breast cancer cell lines. It was previously reported that GW3965 has antiproliferative effects on these 4 different breast cancer cell lines. In the present study, we additi...
ORGANISM(S): Homo sapiens 
2013-07-17 | E-GEOD-34987 | biostudies-arrayexpress
TranscriptomicsExpression data from mutant p53 breast cancer cell line SK-BR-3
Tumor associated mutant p53 proteins often gain new functions for tumorigenesis and tumor progression. It has been shown that mutant p53 can transcriptionally regulate a group of genes, which in turn contributes to mutant p53 gain of function. A mutant p53 interacting protein Pontin binds to mutant ...
ORGANISM(S): Homo sapiens 
2015-06-01 | GSE58140 | GEO
Genomics
RNA sequencing of SK-BR-3 cell line
PRJNA1029741 | ENA
TranscriptomicsScreening target genes of miR-100 in MGC-803 and SK-BR-3 cells
We tried to find the target genes of miR-100 in MGC-803 and SK-BR-3 cells, thus we uesd specific miR-100 inhibitor to knock down the level of miR-100 in the cells, with this condition, we used this mRNA microarray to find the genes whose amount changed. and they may be the target genes that miR-100 ...
ORGANISM(S): Homo sapiens 
2014-01-09 | GSE53909 | GEO
TranscriptomicsTFPI alpha and beta regulate mRNAs involved in cancer biology and in the immune system
Emerging evidences indicate a new role of TFPI in cancer biology. We recently reported that both isoforms of TFPI induced apoptosis and inhibited proliferation of cancer cells. The signaling pathway(s) mediating the effects of TFPI is, however, presently still unclear. Our goal was to further invest...
ORGANISM(S): Homo sapiens 
2012-10-08 | E-GEOD-30037 | biostudies-arrayexpress
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