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MetabolomicsMetabolome and proteome changes in skeletal muscle and blood of pre-weaning calves fed leucine and threonine supplemented diets

In pre-weaning calves, both leucine and threonine play important roles in growth and muscle metabolism. In this study, metabolomics, proteomics and clinical chemistry were used to assess the effects of leucine and threonine supplementation added to milk replacer on 14 newborn Holstein male calves...

2020-02-20 | MTBLS1045 | MetaboLights
MetabolomicsTraining-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganisation of respiratory chain content
Not available
ORGANISM(S): Homo sapiens 
ST001907 | MetabolomicsWorkbench
ProteomicsThe muscle proteome reflects changes in mitochondrial function, cellular stress and proteolysis after 14 days of unilateral lower limb immobilization in active young men
Skeletal muscle unloading due to joint immobilization induces skeletal muscle atrophy. However, the skeletal muscle proteome response to limb immobilization has not been investigated using SWATH methods. This study quantitatively characterized the muscle proteome at baseline, and after 3 and 14 d of...
ORGANISM(S): Homo sapiens (Human) 
2022-08-25 | PXD034908 | Pride
Muscle atrophy Human Skeletal muscle Swath Immobilisation 
ProteomicsHigh intensity interval training remodels the proteome and acetylome in human skeletal muscle
Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD023084 | Pride
Lysine acetylation Exercise Proteome Skeletal muscle Lcms 
ProteomicsDeep muscle proteome - Deep skeletal muscle proteome. Triceps muscle from C57BL6 mouse and C2C12 myotubes were measure by LC-MS.
Deep skeletal muscle proteome. Triceps muscle from C57BL6 mouse and C2C12 myotubes were measure by LC-MS.
ORGANISM(S): Mus musculus (Mouse) 
2015-04-08 | PXD000288 | Pride
Skeletal muscle C2c12 myotubes 
ProteomicsAdaptation-dependent alterations in the human skeletal muscle proteome and phosphoproteome of human skeletal muscle in response to damaging resistance exercise
Resistance exercise (RE) enhances strength, muscle mass, and overall health. Intense RE also triggers rapid muscle damage that is efficiently restored through proteostatic mechanisms in healthy individuals. However, the specific factors and signalling processes active at sites of damage remain poorl...
ORGANISM(S): Homo sapiens (Human) 
2026-04-28 | PXD044976 | Pride
Resistance exercise Proteomics Adaptation Fractionation Human muscle Phosphoproteomics Deadaptation 
ProteomicsMarked increased production of acute phase reactants by skeletal muscle during cancer cachexia
Background Loss of skeletal muscle mass in cancer cachexia is recognized as an independent predictor of mortality. Mechanisms involved in this wasting process and parameters for early diagnosis are not yet clearly defined. As skeletal muscle is considered as a secretory organ, the aim of this prese...
ORGANISM(S): Mus Musculus 
2021-01-24 | PXD019433 | panorama
ProteomicsNAD Depletion in Skeletal Muscle does not Compromise Muscle Function or Accelerate Aging
NAD is a ubiquitous electron carrier essential for energy metabolism and the post translational modification of numerous regulatory proteins. Perturbation of NAD metabolism is considered detrimental to health, with NAD depletion commonly thought to promote aging. However, the extent to which cellula...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-23 | PXD061221 | Pride
Nad metabolism  nampt  skeletal muscle  aging  exercise  mitochondrial supercomplexes 
ProteomicsPlasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in spaceflight-induced deterioration of muscul...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-01 | PXD041806 | JPOST Repository
ProteomicsProteomics of Human Skeletal Muscle
The skeletal muscle proteomics study of vastus lateralis muscle biopsies which were collected from participants from the Genetic and Epigenetic Study of Aging and Laboratory Testing (GESTALT). The participants were free of major diseases, except for controlled hypertension or a history of cancer tha...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD011967 | Pride
Proteomics Skeletal muscle 
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