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MetabolomicsMetabolome and proteome changes in skeletal muscle and blood of pre-weaning calves fed leucine and threonine supplemented diets

In pre-weaning calves, both leucine and threonine play important roles in growth and muscle metabolism. In this study, metabolomics, proteomics and clinical chemistry were used to assess the effects of leucine and threonine supplementation added to milk replacer on 14 newborn Holstein male calves...

2020-02-20 | MTBLS1045 | MetaboLights
MetabolomicsTraining-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganisation of respiratory chain content
Not available
ORGANISM(S): Homo sapiens 
ST001907 | MetabolomicsWorkbench
MetabolomicsMetabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival

The spread of cancer to bone is invariably fatal, with complex cross-talk between tumor cells and the bone microenvironment responsible for driving disease progression. By combining in silico analysis of patient datasets with metabolomic profiling of prostate cancer cells cultured with bone cells...

2024-08-19 | MTBLS3973 | MetaboLights
ProteomicsA mitochondrial proteome profile of type 2 diabetes mellitus in skeletal muscles
The goal of the project is to understand the mitochondrial proteome profiles related to T2DM. We performed comprehensive proteome profiling of mitochondria isolated from skeletal muscles in nine T2DM patients and nine control subjects with normal glucose tolerance (NGT).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-13 | MSV000083560 | MassIVE
ModelsUhlén2015 - Human tissue-based proteome metabolic network - skeletal
Uhlén2015 - Human tissue-based proteome metabolic network - skeletal Human skeletal tissue specific proteome metabolic network This model is described in the article: Tissue-based map of the human proteome Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardin...
2015-01-28 | MODEL1411240009 | BioModels
ProteomicsHigh intensity interval training remodels the proteome and acetylome in human skeletal muscle
Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD023084 | Pride
Lysine acetylation Exercise Proteome Skeletal muscle Lcms 
MetabolomicsEstrogen receptor a deficiency in cardiac myocytes reprograms heart-derived extracellular vesicle proteome and induces obesity in female mice (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST002228 | MetabolomicsWorkbench
MetabolomicsEstrogen receptor α deficiency in cardiac myocytes reprograms heart-derived extracellular vesicle proteome and induces obesity in female mice (Part 1)
Not available
ORGANISM(S): Mus musculus 
ST002229 | MetabolomicsWorkbench
ProteomicsCharacterization of the skeletal muscle proteome in under-nourished old rats
Therefore, undernutrition is common in the elderly where its prevalence varies from 4 to 10% at home, from 15 to 30% in care homes and reaches 30 to 70% in hospitals de-pending on the diagnostic criteria used [10]. Most of all, aging impairs the ability to adapt to undernutrition leading to severe l...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-06-09 | PXD032044 | Pride
Skeletal muscle  aging  sarcopenia  undernutrition  proteome 
ProteomicsThe muscle proteome reflects changes in mitochondrial function, cellular stress and proteolysis after 14 days of unilateral lower limb immobilization in active young men
Skeletal muscle unloading due to joint immobilization induces skeletal muscle atrophy. However, the skeletal muscle proteome response to limb immobilization has not been investigated using SWATH methods. This study quantitatively characterized the muscle proteome at baseline, and after 3 and 14 d of...
ORGANISM(S): Homo sapiens (Human) 
2022-08-25 | PXD034908 | Pride
Muscle atrophy Human Skeletal muscle Swath Immobilisation 
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