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ProteomicsRST1 and RIPR connect the cytosolic RNA exosome to the SKI complex in Arabidopsis
The RNA exosome is a key 3’-5’ exoribonuclease with evolutionary conserved structure and roles. Its cytosolic functions require the co-factors SKI7 and the Ski complex. Here we demonstrate by co-purification experiments that the ARM repeat protein RESURRECTION1 (RST1) and RST1 INTERACTING PROTEIN (R...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-07-17 | PXD013435 | Pride
Rst1 Exo9 Rna exosome Ski7 Ski complex Exosome complex 
TranscriptomicsThe Ski complex binds 80S ribosomes for 3’ to 5’ decay of mRNA
Cytoplasmic degradation of eukaryotic mRNAs in 3’ to 5’ direction is catalyzed by the exosome complex together with the Ski complex and, in the yeast Saccharomyces cerevisiae, the Ski7 protein. This exosome-Ski-system also degrades ribosome-associated aberrant mRNAs lacking a stop codon, a pathway c...
ORGANISM(S): Saccharomyces cerevisiae BY4741 
2017-02-10 | GSE70259 | GEO
UnknownExtraction of mRNA from Stalled Ribosomes by the Ski Complex.
Not available
S-EPMC7934606 | biostudies-literature
UnknownA specialised SKI complex assists the cytoplasmic RNA exosome in the absence of direct association with ribosomes.
Not available
S-EPMC6627227 | biostudies-literature
Genomics
Broad Spectrum Anti-viral Compounds Targeting the SKI Complex
PRJNA1055076 | ENA
UnknownThe SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses.
Not available
S-EPMC7720140 | biostudies-literature
UnknownRST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis.
Not available
S-EPMC6711988 | biostudies-literature
GenomicsSaccharomyces cerevisiae BY4741
The Ski complex binds 80S ribosomes for 3’ to 5’ decay of mRNA
PRJNA288089 | ENA
TranscriptomicsA short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans
A multi-subunit exosome complex is a major eukaryotic exoribonuclease that in the cytoplasm requires the SKI complex for activity. In yeast, SKI forms a heterotetramer and delivers RNA substrates directly into the exosome channel. Such cooperation requires Ski7 protein, which links the exosome and S...
ORGANISM(S): Homo sapiens 
2017-02-15 | GSE77926 | GEO
Genomics
A specialized SKI complex assists the cytoplasmic RNA exosome in the absence of direct association with ribosomes
PRJEB27297 | ENA
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