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ProteomicsIn vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis
Cancer progresses through distinct stages and mouse models recapitulating traits of this progression are frequently used to explore genetic, morphological and pharmacological aspects of tumor development. To complement genomic investigations of this process, here we quantify phosphoproteomic changes...
ORGANISM(S): Mus musculus (Mouse) 
2013-03-13 | PXD000821 | Pride
Mouse Silac Phosphoproteomics Skin carcinogenesis 
ProteomicsSkin cancer-associated S. aureus downregulates DNA repair mechanisms, and promotes oxidative stress and DNA damage in human keratinocytes
Actinic keratoses (AK) are premalignant lesions common on photo-damaged skin that, over time, can progress to squamous cell carcinoma (SCC). A high bacterial load of Staphylococcus aureus is associated with AK and SCC but it is unknown whether this has a direct impact on skin cancer development. To ...
ORGANISM(S): Staphylococcus Capitis Staphylococcus Aureus Staphylococcus Epidermidis Staphylococcus 
2022-05-17 | PXD031676 | panorama
ProteomicsAnd-1 is required for NER repair and promotes skin carcinogenesis
Our project was focused on And-1 regulates NER repair and skin carcinogenesis
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD052800 | Pride
And-1 Ner repair Skin carcinogenesis 
TranscriptomicsErbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation.
Exposure to ultraviolet (UV) irradiation is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States. UV irradiation has a variety of effects on the skin associated with carcinogenesis, including DNA damage and effects on signal transduction. The alterations in...
ORGANISM(S): Mus musculus 
2006-07-01 | E-GEOD-4066 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skin carcinogenesis in FVB/N and Tg.Ac mice
Female FVB/N and Tg.Ac (hemizygotes) mice 3-5 weeks of age were purchased from Harlan UK and Taconic UK, respectively. The mice were contained in an isolator and maintained at 19C with 50% relative humidity and a 12-hour light-dark cycle. Following a 1 week acclimatisation period the dorsal skin o...
ORGANISM(S): Mus musculus 
2005-10-01 | E-MEXP-188 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse expressing human Cathepsin L inhibitor hurpin, skin alterations and increased carcinogenesis.
Aim of this study was to identify gene expression differences in the skin of hurpin (=headpin=serpinB13) transgenic mice in comparison to wildtype mice. Experiment Overall Design: Comparison of 4 transgenic mice with 3 wildtype mice. One wildtye sample was used two times. Experiment Overall Design:...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5236 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse FVB/N wild type and transgenic Tg.AC mice to examine skin papilloma development
This study analyzes gene expression associated with papilloma development in Tg.AC v-Ha-ras transgenic mice and identifies novel genes and biological processes that may be critical to skin carcinogenesis in these mice. Epidermal abrasion was used to synchronously induce epidermal regeneration in FV...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-11136 | biostudies-arrayexpress
TranscriptomicsInflammation-Driven Carcinogenesis is Mediated through STING [skin]
Chronic stimulation of innate immune pathways by microbial agents or damaged tissue is known to promote inflammation-driven tumorigenesis by unclarified mechanisms1-3. Here we demonstrate that mutagenic 7,12-dimethylbenz(a)anthracene (DMBA), etoposide or cisplatin induces nuclear DNA leakage into th...
ORGANISM(S): Mus musculus 
2014-05-31 | E-GEOD-57604 | biostudies-arrayexpress
ProteomicsIdentification of molecular targets of dietary grape-mediated chemoprevention of ultraviolet B skin carcinogenesis: a comparative quantitative proteomics analysis
Grape-supplemented SKH-1 tumor proteomics analysis. Two 10-plex TMT sample sets are included with each TMT sample set being comprised of 5 high pH fractions.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000084316 | MassIVE
UnknownProtective role of cathepsin L in mouse skin carcinogenesis.
Not available
S-EPMC3155742 | biostudies-literature
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