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MetabolomicsAbsorption efficiency of RESV through mouse skin using 3 bases in different tissues
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
2014-12-15 | MTBLS126 | MetaboLights
MetabolomicsDistribution of RESV and its metabolite peaks in mouse tissues after oral and skin administration
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
2014-12-15 | MTBLS125 | MetaboLights
MetabolomicsSelective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights
MetabolomicsA Novel Yeast Extract from a Multi-Stress-Resistant Saccharomyces cerevisiae Confers Potent Antioxidant and UV-Protective Activities to Skin Cells

Strain A154 was obtained through the method of combined mutagenesis and screening with UVC and UVA. This strain has multiple tolerances.


2026-01-31 | MTBLS13804 | MetaboLights
TranscriptomicsMicroarray of reconstructed epidermis from skin models made with cells from African and Caucasian Skin type
The aim of this study was to analyze the in vitro biological epidermal processes occurring in reconstructed skins using cells from breast skin of African and Caucasian skin type color. A exploration of mRNA expression levels in the epidermis of reconstructed skin was undertaken to elucidate the diff...
ORGANISM(S): Homo sapiens 
2020-08-10 | E-MTAB-9433 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq and scTCRseq of human CD8 T cells from blood and skin compartments in Dengue patients
Using a skin-blister induction model established for dengue, we investigated the transcriptional signatures and TCR repertoire of matched CD8 T cells in skin and blood samples
ORGANISM(S): Homo sapiens 
2026-04-14 | E-MTAB-16332 | biostudies-arrayexpress
TranscriptomicsHuman dendritic cell subsets in acute skin inflammation
An unexpected BDCA-2+CD123+CD1a+ dendritic cell (DC) subset comprised a major DC population in acute human sterile skin inflammation. Single-cell RNAseq showed these to be activated DC able to express markers normally associated with plasmacytoid DC, prompting a re-evaluation of previous studies.
ORGANISM(S): Homo sapiens 
2019-12-01 | E-MTAB-8498 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of human skin Langerhans cell and dermal dendritic cells stimulated in vitro with TNF-alpha
Langerhans cells (LCs) are antigen presenting cells residing in the epidermis. Due to the difficulties with obtaining sufficient quantities of LCs for functional studies, many controversies exist about their origin and function. To gain insights into the molecular mechanisms underpinning LC biology ...
ORGANISM(S): Homo sapiens 
2013-12-08 | E-GEOD-49475 | biostudies-arrayexpress
TranscriptomicsscRNAseq of freshly dissociated and cultured skin biopsies
We describe new optimised skin tissue dissociation protocol to digest ex vivo cultured and fresh human skin samples. Using scRNAseq analysis we created skin atlas composition of fresh and cultured skin samples and integrate it with other publicly available skin tissue scRNAdata to compare the qualit...
ORGANISM(S): Homo sapiens 
2022-08-04 | E-MTAB-11509 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human native skin, cultured skin substitute, constituent keratinocytes and fibroblasts to identify gene signatures that are highly characteristic of different tissue types
Cultured skin substitutes, prepared using keratinocytes, fibroblasts and biopolymers, can facilitate closure of massive burn wounds by increasing the availability of autologous tissue for grafting. However, because they contain only two cell types, skin substitutes cannot replace all of the functio...
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3204 | biostudies-arrayexpress
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