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TranscriptomicsMicroarray data of rat expanded skin tissue
The skin expansion technique is widely applied in Plastic and Reconstructive Surgeries. Skin expansion induces skin growth and is an ideal approach for large-scale skin deformity reconstruction. However, the capacity for skin expansion is limited and searching for ways to enhance the expansion effic...
ORGANISM(S): Rattus norvegicus 
2020-03-04 | E-MTAB-8304 | biostudies-arrayexpress
TranscriptomicsMultiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma - Spatial Transcriptomics - 10X Visium
Our understanding of how human skin cells differ according to anatomical site and tumour formation is limited. To address this we have created a multi-scale spatial atlas of healthy skin and basal cell carcinoma (BCC), incorporating in vivo optical coherence tomography, single cell RNA sequencing, s...
ORGANISM(S): Homo sapiens 
2023-12-22 | E-MTAB-13085 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of lesional and non-lesional skin from atopic dermatitis patients and healthy individuals
Atopic dermatitis (AD) is a common inflammatory skin disease with a T(H)2 and T22 immune polarity. Despite recent data showing a genetic predisposition to epidermal barrier defects in some patients, a fundamental debate still exists regarding the role of barrier abnormalities versus immune responses...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-GEOD-32924 | biostudies-arrayexpress
ProteomicsC9ORF72 repeat expansion affects the proteome of primary skin fibroblasts in ALS and FTD
The study design involves the proteomics characterization of primary skin fibroblast cell lines derived from skin biopsies from patients affected by either amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Patients enrolled were divided in three groups: 1) ALS patients carrying t...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD023866 | Pride
Human Hdmse Als Fibroblast 
TranscriptomicsMultiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma - Spatial Transcriptomics - 10X Visium
Our understanding of how human skin cells differ according to body site and tumour formation is limited. To address this we have created a multi-scale spatial atlas of healthy skin and basal cell carcinoma (BCC), incorporating in vivo optical coherence tomography, single cell RNA sequencing, spatia...
ORGANISM(S): Homo sapiens 
2023-12-22 | E-MTAB-13084 | biostudies-arrayexpress
GenomicsscRNAseq of stretch-mediated skin expansion in mouse
scRNAseq of stretch-mediated skin expansion in mouse
PRJNA1201155 | ENA
TranscriptomicsSomatic copy-number mosaicism in human skin revealed by induced pluripotent stem cells (sequencing)
Reprogramming human somatic cells into induced pluripotent stem cells (iPSC) has been suspected of causing de novo copy number variations (CNVs). To explore this issue, we performed a whole-genome and transcriptome analysis of 20 human iPSC lines derived from primary skin fibroblasts of 7 individual...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-41716 | biostudies-arrayexpress
TranscriptomicsStudy of stem cells and progenitor cells in K14 Snail mice
Expression of the EMT-inducing transcription factor Snail is enhanced in different human cancers. To investigate the in vivo role of Snail during progression of epithelial cancer, we used a mouse model with skin-specific overexpression of Snail. Snail transgenic mice spontaneously developed distinct...
ORGANISM(S): Mus musculus 
2014-07-09 | E-GEOD-48859 | biostudies-arrayexpress
GenomicsDefining the role of fibroblasts in skin expansion
Defining the role of fibroblasts in skin expansion
PRJNA1435788 | ENA
TranscriptomicsRNA sequencing of primary thymic, bone and skin mesenchymal cells
Purpose : Elucidate post-natal role of SCA1+ thymic mesenchymal cells (tMCs) and evaluate the functional overlap between thymic, bone and skin MCs. Method : By high speed cell sorting, we isolated primary MCs (Lin- SCA1+ cells) from mouse thymus, bone and skin. We extracted their respective total RN...
ORGANISM(S): Mus musculus 
2016-02-26 | E-GEOD-73175 | biostudies-arrayexpress
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