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MetabolomicsAbsorption efficiency of RESV through mouse skin using 3 bases in different tissues
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
2014-12-15 | MTBLS126 | MetaboLights
MetabolomicsDistribution of RESV and its metabolite peaks in mouse tissues after oral and skin administration
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
2014-12-15 | MTBLS125 | MetaboLights
MetabolomicsMetabolic Reprogramming and Reliance in Human Skin Wound Healing
Impaired skin wound healing is a significant global health issue, especially among the elderly. Wound healing is a well-orchestrated process involving the sequential phases of inflammation, proliferation, and tissue remodeling. Although wound healing is a highly dynamic and energy-requiring process,...
2024-07-02 | MTBLS3315 | MetaboLights
ProteomicsThe human pathobiont Malassezia furfur secreted protease MfSAP1 regulates cell dispersal and exacerbates skin inflammation
Malassezia forms the dominant eukaryotic microbial community on the human skin. The Malassezia genus possesses a repertoire of secretory hydrolytic enzymes involved in protein and lipid metabolism which alter the external cutaneous environment. The exact role of most Malassezia secreted enzymes, inc...
ORGANISM(S): Cellular Organisms 
2022-11-11 | PXD033336 | JPOST Repository
TranscriptomicsHuman dendritic cell subsets in acute skin inflammation
An unexpected BDCA-2+CD123+CD1a+ dendritic cell (DC) subset comprised a major DC population in acute human sterile skin inflammation. Single-cell RNAseq showed these to be activated DC able to express markers normally associated with plasmacytoid DC, prompting a re-evaluation of previous studies.
ORGANISM(S): Homo sapiens 
2019-12-01 | E-MTAB-8498 | biostudies-arrayexpress
TranscriptomicsGenetic architecture of murine skin inflammation and tumor susceptibility
Gene expression in self-renewing epithelial tissues is controlled by cis- and trans-activating regulatory factors that mediate responses to exogenous agents capable of causing tissue damage, infection, inflammation, or tumorigenesis. We used network construction methods to analyze the genetic archi...
ORGANISM(S): Mus musculus 
2008-12-31 | E-GEOD-12248 | biostudies-arrayexpress
TranscriptomicsErbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation.
Exposure to ultraviolet (UV) irradiation is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States. UV irradiation has a variety of effects on the skin associated with carcinogenesis, including DNA damage and effects on signal transduction. The alterations in...
ORGANISM(S): Mus musculus 
2006-07-01 | E-GEOD-4066 | biostudies-arrayexpress
TranscriptomicsSuppression of molecular inflammatory pathways by Toll-like Receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation
Psoriasis is a complex inflammatory disease resulting from the activation of T helper (Th) 1 and Th17 cells. Recent evidence suggests that abnormal activation of Toll-like receptors (TLRs) 7, 8 and 9 contributes to the initiation and maintenance of psoriasis. We have evaluated the effects of TLR a...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-50400 | biostudies-arrayexpress
TranscriptomicsEnvironmental factors transmitted by aryl hydrocarbon receptor influence severity of psoriatic skin inflammation [Affymetrix]
Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanism is unknown. Here we show that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis. AhR-activati...
ORGANISM(S): Mus musculus 
2014-06-11 | E-GEOD-47607 | biostudies-arrayexpress
TranscriptomicsEnvironmental factors transmitted by aryl hydrocarbon receptor influence severity of psoriatic skin inflammation [RNA-Seq]
Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanism is unknown. Here we show that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis. AhR-activati...
ORGANISM(S): Homo sapiens 
2014-06-11 | E-GEOD-47944 | biostudies-arrayexpress
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