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ProteomicsA Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription
Cells typically regulate their size within a relatively tight range by coupling growth to the cell division cycle using a dedicated set of molecular mechanisms. In budding yeast, cells are born with a similar amount of the G1/S inhibitor protein Whi5 that is then diluted by growth throughout G1. As ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-03-31 | PXD075635 | Pride
Whi5 Cell size Size scaling 
ProteomicsGenome dilution by cell growth drives starvation-like proteome remodeling in yeast and mammalian cells
Cell size is tightly controlled in healthy tissues and single-celled organisms, but it remains unclear how cell size influences physiology. Increasing cell size was recently shown to remodel the proteomes of cultured human cells, demonstrating that large and small cells of the same type can be compo...
ORGANISM(S): Mus musculus (Mouse) Saccharomyces cerevisiae (Baker's yeast) 
2024-06-05 | PXD052786 | Pride
Yeast Tmt Human Silac 
ProteomicsCell size-dependent mRNA transcription drives proteome remodeling
Increasing cell size drives proteomic changes that impact cell physiology. However, the molecular basis of size-dependent proteome remodeling has remained unclear. Here, we develop an inducible Cyclin D1 expression system in human cells to generate populations of proliferating cells spanning over a ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-03 | PXD076071 | Pride
Transcription Protein turnover Cell size Size scaling 
UnknownA Precise Cdk Activity Threshold Determines Passage through the Restriction Point.
Not available
S-EPMC5790185 | biostudies-literature
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