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ProteomicsA Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription
Cells typically regulate their size within a relatively tight range by coupling growth to the cell division cycle using a dedicated set of molecular mechanisms. In budding yeast, cells are born with a similar amount of the G1/S inhibitor protein Whi5 that is then diluted by growth throughout G1. As ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-03-31 | PXD075635 | Pride
Whi5 Cell size Size scaling 
ProteomicsFission yeast Whi5-GFP interactome in MM and in MM-N (16 hours)
We performed mass-spectrometry analysis of proteins co-purifying with Whi5, a predicted repressor of the MBF transcriptional complex. Whi5 was tagged with GFP at its C-terminal end and expressed from its endogenous promoter at its chromosomal locus. Whi5-GFP was immunoprecipitated from cells growing...
ORGANISM(S): Schizosaccharomyces pombe 927 
2025-12-20 | PXD057886 | Pride
Transcription Mbf Nitrogen starvation Quiescence 
GenomicsFission yeast Whi5 represses MBF-dependent transcription in quiescent cells
Fission yeast Whi5 represses MBF-dependent transcription in quiescent cells
PRJNA1201153 | ENA
GenomicsFission yeast Whi5 represses MBF-dependent transcription in quiescent cells II
Fission yeast Whi5 represses MBF-dependent transcription in quiescent cells II
PRJNA1205779 | ENA
TranscriptomicsFission yeast Whi5 represses MBF-dependent transcription in quiescent cells
When cells arrest the cell cycle in G1 to enter the non-dividing quiescent state, the transcriptional machinery that promotes G1/S transition must be inactivated. Central to this regulation is Whi5, in budding yeast, and the Retinoblastoma (Rb) protein, in mammalian cells, acting as repressors of th...
ORGANISM(S): Schizosaccharomyces pombe 
2025-12-20 | GSE285081 | GEO
TranscriptomicsFission yeast Whi5 represses MBF-dependent transcription in quiescent cells II
When cells arrest the cell cycle in G1 to enter the non-dividing quiescent state, the transcriptional machinery that promotes G1/S transition must be inactivated. Central to this regulation is Whi5, in budding yeast, and the Retinoblastoma (Rb) protein, in mammalian cells, acting as repressors of th...
ORGANISM(S): Schizosaccharomyces pombe 
2025-12-20 | GSE285763 | GEO
UnknownFission yeast Whi5 represses MBF-dependent transcription in quiescent cells.
Not available
S-EPMC12828573 | biostudies-literature
UnknownCln3 can work independently of Whi5 on the cell size for Start in yeast.
Not available
S-EPMC12633300 | biostudies-literature
UnknownThe G1/S repressor WHI5 is expressed at similar levels throughout the cell cycle.
Not available
S-EPMC9284753 | biostudies-literature
UnknownDilution of the cell cycle inhibitor Whi5 controls budding-yeast cell size.
Not available
S-EPMC4600446 | biostudies-literature
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