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TranscriptomicsMicroRNA-223 and miR-143 are important systemic biomarkers for disease activity in psoriasis
Background: Psoriasis is a systemic inflammatory skin disease. MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that recently have been found in the blood to be relevant as disease biomarkers. Objective: We aimed to explore miRNAs potential as blood biomarkers for psoriasis. Methods:...
ORGANISM(S): Homo sapiens 
2014-06-10 | E-GEOD-55515 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skin during elicitation of allergic contact dermatitis - time series
Genes involved in the inflammatory response resulting in allergic contact dermatitis (ACD) are only partly known. In this study, we introduce the use of high density oligonucleotide arrays for gene expression profiling in human skin during the elicitation of ACD. Skin biopsies from normal and nickel...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6281 | biostudies-arrayexpress
ProteomicsSpatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Human skin provides both physical integrity and immunological protection from the external environment, using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically charact...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-15 | MSV000088236 | MassIVE
TranscriptomicsComparison of microRNA expression using different preservation methods of matched psoriatic skin samples
MicroRNA expression profiling in matched lesional skin samples from 25 patients with psoriasis using the miRNA analysis platform miRCURY LNATM MicroRNA array (v. 11.0) (Exiqon). Aim: To explore the effect of three different preservation methods (Formalin-fixation paraffin-embedding (FFPE), frozen (F...
ORGANISM(S): Homo sapiens 
2012-03-22 | E-GEOD-28729 | biostudies-arrayexpress
TranscriptomicsLaser capture microdissection followed by next-generation sequencing identifies disease-related microRNAs in psoriatic skin that mirror the systemic psoriatic miRNome
Psoriasis is a systemic disease with cutaneous manifestations. MicroRNAs (miRNAs) are non-coding RNA molecules that are differentially expressed in psoriatic skin, however; only few miRNAs have been localized to specific cells or regions of psoriatic lesions. We used laser capture microdissection (L...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-57012 | biostudies-arrayexpress
TranscriptomicsDiagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)
Cutaneous T-cell lymphomas (CTCL) are the most frequent primary skin lymphomas. Nevertheless, diagnosis of early disease has proven difficult due to a clinical and histological resemblance to benign inflammatory skin diseases. To address if microRNA (miRNA) profiling can discriminate CTCL from benig...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31408 | biostudies-arrayexpress
TranscriptomicsRepeated monthly epicutaneous challenges with diphenylcyclopropenone (DPCP).
The level of reactivity in pre-sensitized individuals following repeated epicutaneous challenges with diphenylcyclopropenone (DPCP) remains unknown. We studied the kinetics and time-course of the developing reactivity to this potent contact sensitizer using genome-wide gene expression data Ten healt...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-71996 | biostudies-arrayexpress
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