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MetabolomicsThe Leiden Longevity Study: Identification of biomarkers of the rate of ageing
The aim of the study is to identify genetic mechanisms of longevity and to characterize their interaction with the environment. Using the results the future health of people without familial longevity can be improved in old age. Long-lived siblings of European descent were recruited together with th...
2019-07-11 | MTBLS974 | MetaboLights
GenomicsDepartment of Human Genetics, Radboud University Nijmegen Medical Centre, Data Access Committee
Data Access Committee EGAC00001000076
EGAC00001000076 | EGA
GenomicsLeiden Longevity Study Data Access Committee
Data Access Committee EGAC00001000210
EGAC00001000210 | EGA
GenomicsLLS_2SAMPLES_DATASET - samples
Description not provided
EGAD00001001001 | EGA
Genomicsena-DATASET-RUNMC-17-07-2014-15:19:55:636-69 - samples
Illumina HiSeq paired-end exome sequencing of a trio and singleton.
EGAD00001000883 | EGA
GenomicsBenchmark and validation of whole exome sequencing of a trio and singleton
Whole exome paired-end sequencing data was obtained for a trio and a fourth unrelated individual sequenced to high depth (95x) using a paired-end library with the Illumina HiSeq platform and aligned by BWA 0.5.9. The bam files were analysed and experimentally vaidated for the novel insertion of mobi...
EGAS00001000852 | EGA
GenomicsWhole genome DNA sequencing for two long-lived humans.
Two long-lived human samples were sequenced to a mean 20x coverage genome wide. Sequencing was done using the Illumina hi-seq platform, alignment to GRCh37/hg19 reference genome was done using the BWA alignment tool.
EGAS00001000877 | EGA
UnknownThe co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific.
Not available
S-EPMC4326891 | biostudies-literature
UnknownMetabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium.
Not available
S-EPMC6690953 | biostudies-literature
GenomicsDNA methylation and the adverse metabolic outcomes of adiposity
Overweight and obesity affect ~1.5 billion people worldwide, and are major risk factors for type-2 diabetes (T2D), cardiovascular disease and related metabolic and inflammatory disturbances.1,2 Although the mechanisms linking adiposity to its clinical sequelae are poorly understood, recent studies s...
EGAS00001001922 | EGA
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