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TranscriptomicsDeconvolving the recognition of DNA shape from sequence
Binding of transcription factors to DNA is mediated by the recognition of the chemical signatures of the DNA bases and the three-dimensional shape of the DNA molecule. The direct contribution of DNA shape to DNA-binding specificity has been difficult to assess, as DNA shape is a consequence of its ...
ORGANISM(S): Drosophila melanogaster 
2015-01-21 | E-GEOD-65073 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of Ubx and Hth in 3rd thoracic imaginal discs
The Hox genes are responsible for generating morphological diversity along the anterior-posterior axis during animal development. The Drosophila Hox gene Ultrabithorax (Ubx), for example, is required for specifying the identity of the third thoracic (T3) segment of the adult, which includes the dors...
ORGANISM(S): Drosophila melanogaster 
2011-01-21 | E-GEOD-26793 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of Sd and Yki in imaginal discs
The transcription cofactor Yki drives growth and proliferation in part by controlling mitochondrial network formation. To determine if Yki and Sd are directly bound to DNA corresponding to mitochondrial genes, we used chromatin immunoprecipitation and whole genome tiling arrays (ChIP-chip) to identi...
ORGANISM(S): Drosophila melanogaster 
2012-10-03 | E-GEOD-26678 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of Yki and GAF in embryos and wing imaginal discs [RNA-Seq]
The Hippo pathway regulates metazoan growth, acting through the transcriptional co-activators Yorkie (in Drosophila) and Yap and Taz (in vertebrates). Much attention has been focused on upstream regulators of Yorkie and its homologues. In contrast, the mechanisms by which they actually promote trans...
ORGANISM(S): Drosophila melanogaster 
2013-02-07 | E-GEOD-43129 | biostudies-arrayexpress
GenomicsGenome-wide binding of Yki and GAF in embryos and wing imaginal discs [ChIP-Seq]
The Hippo pathway regulates metazoan growth, acting through the transcriptional co-activators Yorkie (in Drosophila) and Yap and Taz (in vertebrates). Much attention has been focused on upstream regulators of Yorkie and its homologues. In contrast, the mechanisms by which they actually promote trans...
ORGANISM(S): Drosophila melanogaster 
2013-02-07 | E-GEOD-38594 | biostudies-arrayexpress
GenomicsDiverse patterns of genome-wide DNA targeting by transcriptional regulators in Drosophila melanogaster
Understanding the regulatory genome remains a significant challenge. Annotation of regulatory elements and identification of the transcription factors (TFs) targeting these elements are key steps in understanding how a given cell interprets its genetic blueprint. One goal of the modENCODE (model or...
ORGANISM(S): Drosophila melanogaster 
2013-08-16 | E-GEOD-49899 | biostudies-arrayexpress
GenomicsCG8478_S2_cells_ChIP-seq
modENCODE_submission_4966 This submission comes from a modENCODE project of Kevin White. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The White Lab is aiming to map the association of all the Transcription Factors (TF) on the genome of Drosophila melanogaster...
ORGANISM(S): Drosophila melanogaster 
2013-08-28 | E-GEOD-50364 | biostudies-arrayexpress
GenomicsH_Kc_cells_ChIP-seq
modENCODE_submission_4983 This submission comes from a modENCODE project of Kevin White. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The White Lab is aiming to map the association of all the Transcription Factors (TF) on the genome of Drosophila melanogaster...
ORGANISM(S): Drosophila melanogaster 
2013-12-21 | E-GEOD-53557 | biostudies-arrayexpress
Genomicsinsv_Kc_cells_ChIP-seq
modENCODE_submission_5001 This submission comes from a modENCODE project of Kevin White. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The White Lab is aiming to map the association of all the Transcription Factors (TF) on the genome of Drosophila melanogaster...
ORGANISM(S): Drosophila melanogaster 
2013-08-28 | E-GEOD-50371 | biostudies-arrayexpress
GenomicsSin3A_Kc-seq
modENCODE_submission_4100 This submission comes from a modENCODE project of Kevin White. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The White Lab is aiming to map the association of many of the non-histone chromosomal proteins on the genome of Drosophila me...
ORGANISM(S): Drosophila melanogaster 
2013-08-28 | E-GEOD-50353 | biostudies-arrayexpress
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