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ProteomicsInteraction proteomics of WT and disease variants of the human Creatine Transporter (SLC6A8)
Creatine is an essential metabolite for the storage and rapid supply of energy in muscle and nerve cells. In humans, the creatine deficiency syndrome (CDS) is manifested by impaired metabolism, transport, and distribution of creatine throughout the body leading to severe forms of mental disabilities...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD047111 | Pride
Ap-ms Slc6a8 Protein interactions Pathogenic variants 
GenomicsThe role and mechanism of hypoxia-induced SLC6A8 up-regulation in HCC progression
The role and mechanism of hypoxia-induced SLC6A8 up-regulation in HCC progression
PRJNA1224831 | ENA
TranscriptomicsThe role and mechanism of hypoxia-induced SLC6A8 up-regulation in HCC progression
Hypoxia is a hallmark of solid tumors and profoundly affects the malignant phenotypes of cancer cells. We find that the creatine transporter solute carrier family 6, member 8 (SLC6A8) is upregulated in hypoxic HCC cells. Hypoxia-induced creatine accumulation drives metabolic reprogramming and antago...
ORGANISM(S): Homo sapiens 
2025-07-23 | GSE289804 | GEO
GenomicsSLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer
SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer
PRJNA1203678 | ENA
UnknownSLC6A8 is a Potential Biomarker for Poor Prognosis in Lung Adenocarcinoma.
Not available
S-EPMC9185669 | biostudies-literature
UnknownPan-Cancer Analysis of the Oncogenic and Immunological Role of Solute Carrier Family 6 Member 8 (SLC6A8).
Not available
S-EPMC9428493 | biostudies-literature
TranscriptomicsSLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer
We discovered, through untargeted metabolomics, that creatine promotes ferroptosis in colorectal cancer. Our study identifies ERK2 as a creatine sensor that mediates active FSP1 and ferroptosis resistance, and highlights the potential of targeting tumor SLC6A8 for cancer treatment.
ORGANISM(S): Homo sapiens 
2025-09-05 | GSE285466 | GEO
UnknownSLC6A8 is involved in the progression of non-small cell lung cancer through the Notch signaling pathway.
Not available
S-EPMC7940877 | biostudies-literature
UnknownNovel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency.
Not available
S-EPMC11574759 | biostudies-literature
UnknownHigh prevalence of SLC6A8 deficiency in X-linked mental retardation.
Not available
S-EPMC1182013 | biostudies-literature
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