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MetabolomicsChronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress

Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of the mechanisms involved have focused largely on acute sleep deprivation. To identify metabolic consequences of chronically reduced sleep, we conducted unbiased metabolomics on heads of three adult Drosoph...

2023-03-18 | MTBLS3318 | MetaboLights
TranscriptomicsEffect of 12 hour sleep restriction on the transcriptome of mice carying a human Per3 polymorphism
In humans, a primate-specific variable-number tandem-repeat (VNTR) polymorphism (4 or 5 repeats 54 nt in length) in the circadian gene PER3 is associated with differences in sleep timing and homeostatic responses to sleep loss. We investigated the effects of this polymorphism on circadian rhythmicit...
ORGANISM(S): Mus musculus 
2014-03-11 | E-GEOD-55494 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain Homer1a-expressing cells after sleep deprivation
To gain insight into the molecular changes of sleep need, this study addresses gene expression changes in a subpopulation of neurons selectively activated by sleep deprivation. Whole brain expression analyses after 6h sleep deprivation clearly indicate that Homer1a is the best index of sleep need, c...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9443 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain from 3 inbred strains after sleep deprivation
This SuperSeries is composed of the following subset Series:; GSE9441: The effect of sleep deprivation on gene expression in the brain and the liver of three inbred mouse strains; GSE9442: Molecular correlates of sleep deprivation in the brain of three inbred mouse strains in an around-the-clock exp...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9444 | biostudies-arrayexpress
TranscriptomicsIdentification of Sleep Regulatory Genes in Flies Mutant for the Clock Gene cycle
Extended periods of waking result in physiological impairments in humans, rats, and flies. Sleep homeostasis, the increase in sleep observed following sleep loss, is believed to counter the negative effects of prolonged waking by restoring vital biological processes that are degraded during sleep de...
ORGANISM(S): Drosophila melanogaster 
2014-04-15 | E-GEOD-18550 | biostudies-arrayexpress
TranscriptomicsA human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-03-11 | E-GEOD-55255 | biostudies-arrayexpress
TranscriptomicsEffect of ultradian light-dark cycles on the transcriptome of mice carying a human Per3 polymorphism
In humans, a primate-specific variable-number tandem-repeat (VNTR) polymorphism (4 or 5 repeats 54 nt in length) in the circadian gene PER3 is associated with differences in sleep timing and homeostatic responses to sleep loss. We investigated the effects of this polymorphism on circadian rhythmicit...
ORGANISM(S): Mus musculus 
2014-03-11 | E-GEOD-55495 | biostudies-arrayexpress
TranscriptomicsEffect of sleep restriction on the human transcriptome during extended wakefulness
In a cross balanced design human subjects were given one week of sufficient sleep and insufficient sleep (6 h per day). Following each of these conditions they were then kept awake for a day, a night and the subsequent day. During each of these periods of extended wakefulness 10 blood samples were t...
ORGANISM(S): Homo sapiens 
2013-02-27 | E-GEOD-39445 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain and liver from 3 inbred strains - the effect of sleep deprivation on gene expression
These studies adress differential changes in gene expression between 6h sleep deprived and control mice in the brain and the liver. We profiled gene expression in three different inbred strains to understand the influence of genetic background. Experiment Overall Design: Experiments were performed o...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9441 | biostudies-arrayexpress
TranscriptomicsEpigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation
Background: Late gestational sleep fragmentation (LG-SF) is one of the major perturbations associated with sleep apnea and other sleep disorders during pregnancy. Objectives: To investigate the effects of late LG-SF on the epigenome of visceral white adipose tissue (VWAT) in the offspring. Methods: ...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-63208 | biostudies-arrayexpress
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