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TranscriptomicsRNA-seq of blood taken from patients suffering from sleeping sickness and infected with Trypanosoma brucei rhodesiense
Shotgun sequencing of sleeping sickness patient blood. WARNING: these results cannot be compared with those from trypanosome poly(A)+ mRNA, because the poly(A) selection introduces substantial bias, including loss of long mRNAs. Details will appear in the publication. These are additional sequencing...
ORGANISM(S): Homo sapiens 
2018-06-18 | E-MTAB-5614 | biostudies-arrayexpress
UnknownThree drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda.
Not available
S-EPMC1687208 | biostudies-literature
TranscriptomicsTranscriptome analysis of two life cycle stages of Trypanosoma brucei gambiense
Trypanosoma brucei gambiense is the causative agent of the fatal human disease African sleeping sickness. Here we have compared the transcriptome of two different life cycle stages, the potentially human-infective bloodstream form and the non-human-infective procyclic stage, using digital gene expre...
ORGANISM(S): Trypanosoma brucei gambiense 
2010-07-21 | E-GEOD-18065 | biostudies-arrayexpress
GenomicsRNA-seq of blood taken from patients suffering from sleeping sickness and infected with Trypanosoma brucei rhodesiense
RNA-seq of blood taken from patients suffering from sleeping sickness and infected with Trypanosoma brucei rhodesiense
PRJEB27207 | ENA
MetabolomicsMetabolomics identifies multiple candidate biomarkers to diagnose and stage human African trypanosomiasis
Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the blood-brain barrier in the cerebrospinal flui...
2018-01-24 | MTBLS413 | MetaboLights
ProteomicsGlobal profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite Trypanosoma brucei via chemical proteomics
The enzyme N-myristoyltransferase (NMT) catalyses the essential fatty acylation of substrate proteins with myristic acid in eukaryotes and is a validated drug target in the parasite Trypanosoma brucei, the causative agent of African trypanosomiasis (sleeping sickness). N-Myristoylation typically med...
ORGANISM(S): Trypanosoma brucei 
2016-05-17 | PXD004053 | Pride
Target validation N-myristoylation Chemical proteomics Human african trypanosomiasis Click chemistry Protein lipidation 
TranscriptomicsTranscription profiling time series of kidney, liver and spleen from three strains of mice infected with Trypanosoma congolense to investigate strain differences in susceptibility
In this experiment, mice from 3 strains A/J, Balb C and C57Bl6 were infected with Trypanosoma Congolense, IL1180 clone, African sleeping sickness, a disease which affects cattle in sub-saharan Africa. These mouse strains were chosen because they are a model for tolerance to infection in cattle, wi...
ORGANISM(S): Mus musculus 
2007-08-21 | E-MEXP-1190 | biostudies-arrayexpress
UnknownMolecular dipstick test for diagnosis of sleeping sickness.
Not available
S-EPMC1594664 | biostudies-literature
UnknownSleeping sickness in Uganda: a thin line between two fatal diseases.
Not available
S-EPMC1289320 | biostudies-literature
UnknownThe dispersal ecology of Rhodesian sleeping sickness following its introduction to a new area.
Not available
S-EPMC3794918 | biostudies-literature
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