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GenomicsSLF2 in DLBCL
Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs CHK1 mediated DNA repair
PRJEB47681 | ENA
ProteomicsActionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage Response
The DNA damage response (DDR) acts as a barrier to malignant transformation and is often impaired during tumorigenesis. Exploiting the impaired DDR can be a promising therapeutic strategy; however, the mechanisms of inactivation and corresponding biomarkers are incompletely understood. Starting from...
ORGANISM(S): Homo sapiens (Human) 
2023-07-21 | PXD041834 | Pride
B-cell lymphoma Slf2 Dna damage response 
GenomicsSilencing of unintegrated HIV-1 by SLF2 and the SMC5/6 complex
Silencing of unintegrated HIV-1 by SLF2 and the SMC5/6 complex
PRJNA658542 | ENA
ProteomicsActionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage Response
The DNA damage response (DDR) acts as a barrier to malignant transformation and is often impaired during tumorigenesis. Exploiting the impaired DDR can be a promising therapeutic strategy; however, the mechanisms of inactivation and corresponding biomarkers are incompletely understood. Starting from...
ORGANISM(S): Homo sapiens (Human) 
2023-07-21 | PXD041851 | Pride
B-cell lymphoma Slf2 Chromatin proteome Dna damage response 
GenomicsSilencing of unintegrated HIV-1 by SLF2 and the SMC5/6 complex
Silencing of nuclear DNA is an essential feature of the innate immune response to invading pathogens. Early in lentiviral infection, unintegrated viral cDNA accumulates in the nucleus, yet remains poorly expressed. In HIV-1-like lentiviruses, the Vpr accessory protein enhances unintegrated viral DNA...
ORGANISM(S): Homo sapiens 
2021-03-01 | GSE156630 | GEO
UnknownActionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response.
Not available
S-EPMC10493575 | biostudies-literature
UnknownSMC5/6-mediated plasmid silencing is directed by SIMC1-SLF2 and antagonized by the SV40 large T antigen.
Not available
S-EPMC12656486 | biostudies-literature
UnknownThe Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.
Not available
S-EPMC9708086 | biostudies-literature
UnknownPathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.
Not available
S-EPMC9636423 | biostudies-literature
GenomicsSLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome [ATAC-seq]
Pathogenic variants in SLF2 and SMC5 cause a developmental disorder known as Atelis Syndrome, characterized by microcephaly, short stature, and hematological abnormalities, most notably anemia and lymphopenia. However, its clinical relevance to hematology has not yet been established, and the underl...
ORGANISM(S): Homo sapiens 
2026-08-06 | GSE316079 | GEO
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