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TranscriptomicsSTAT1 independent control of a neurotropic measles virus challenge in primary neurons and infected mice
The objective of this study was to compare the ability of mice that lack STAT1 to resolve a neurotropic viral challenge, and to assess the ability of neurons obtained from these mice to be effectively cleared of virus by interferon gamma For the array, primary neurons were isolated from embryonic mi...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-33057 | biostudies-arrayexpress
TranscriptomicsGene expression change in Skov3 after EZH2 knockdown
To identify genes whose expression was suppressed by EZH2, we performed gene expression microarray analysis in control and EZH2 knockdown human SKOV3 EOC cells. Two individual short hairpin RNAs to the human EZH2 gene (shEZH2) were used to limit potential off-target effects. Two individual short hai...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-31433 | biostudies-arrayexpress
Transcriptomics17beta-estradiol (E2)-regulated gene expression across time in estrogen-dependent and estrogen deprivation-resistant MCF-7-derived breast cancer cell lines.
A series of MCF-7 variants were previously developed that are either estrogen-dependent for growth (MCF-7:WS8 cells), or resistant to estrogen deprivation and refractory (MCF-7:2A) or sensitive (MCF-7:5C) to E2-induced apoptosis. To identify genes associated with E2-induced apoptosis, estrogen depri...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-29917 | biostudies-arrayexpress
TranscriptomicsExpression Array analysis of MTAP in HT080 cells
Methylthioadenosine Phosphorylase (MTAP) is a tumor suppressor gene that encodes an enzyme responsible for the catabolism of the polyamine byproduct 5′deoxy-5′-methylthioadenosine (MTA). To elucidate the mechanism by which MTAP inhibits tumor formation, we have created isogenic MTAP+ and MTAP- HT10...
ORGANISM(S): Homo sapiens 
2014-04-30 | E-GEOD-56112 | biostudies-arrayexpress
TranscriptomicsDefining the Genomic Signature of the Parous Breast
It is widely accepted that a woman’s lifetime risk of developing breast cancer at menopause is reduced by early full term pregnancy and multiparity. This phenomenon is associated with the development and differentiation of the breast, which ultimately imprints a specific genomic profile in the mam...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-26457 | biostudies-arrayexpress
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