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MetabolomicsGlycoalkaloid composition explains variation in slug resistance in Solanum dulcamara
In natural environments, plants have to deal with a wide range of different herbivores whose communities vary in time and space. It is believed that the chemical diversity within plant species has mainly arisen from selection pressures exerted by herbivores. So far, the effects of chemical diversity...
2019-06-17 | MTBLS738 | MetaboLights
TranscriptomicsThe invasion promoter Slug is a critical cell cycle regulator
Background: The well-characterized function of the transcriptional repressor, Slug, is to promote EMT and tumor invasion/metastasis by down-regulating E-cadherin expression. In this study, we investigated the significance of Slug during the S phase. Method: Slug mRNA expression was isolated from thy...
ORGANISM(S): Homo sapiens 
2012-02-09 | E-GEOD-35617 | biostudies-arrayexpress
TranscriptomicsExpression analysis of HepG2, HepG2-slug and HepG2-slug on Matrigel
Investigation of whole genome gene expression level changes in hepatocellular carcinoma cell line hepG2 in regular culture, hepG2-slug in regular culture and hepG2-slug on Matrigel. Whole genome gene expression level changes have been compared in hepatocellular carcinoma cell line hepG2 in regular c...
ORGANISM(S): Homo sapiens 
2012-09-21 | E-GEOD-41026 | biostudies-arrayexpress
TranscriptomicsCell state transitions regulated by Slug are critical for tissue regeneration and tumor initiation [Agilent microarray samples]
Alterations that perturb differentiation and cell state transitions can lead to defects in development, function and the genesis of cancer. Studying cellular plasticity at high resolution and in real time has proven difficult using existing methods. Here, we use a quantitative approach to gain insig...
ORGANISM(S): Homo sapiens 
2014-06-23 | E-GEOD-54713 | biostudies-arrayexpress
TranscriptomicsSlug overexpression
This SuperSeries is composed of the following subset Series: GSE41026: Expression analysis of HepG2, HepG2-slug and HepG2-slug on Matrigel GSE41027: Chip-chip from HepG2 cells and HepG2 cells with slug overexpression Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-09-21 | E-GEOD-41028 | biostudies-arrayexpress
TranscriptomicsInfluence of Slug/SNAI2 on global gene expression in CRC cells and tumors
To establish the role of Slug in CRC, we created a genetic CRC model for Slug expression. As parental cells, we selected HT-29 cells that display a pronounced epithelial phe-notype. HT-29 cells were transfected with Slug, and two stable Slug-expressing clones. (Slug1, Slug2) were isolated. As transf...
ORGANISM(S): Mus musculus 
2022-06-11 | E-MTAB-11812 | biostudies-arrayexpress
TranscriptomicsSlug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU-treatment
In pancreatic cancer the survival rate is low, as the available treatment options usually only extend survival and seldom produce a cure. Drug resistance and disease reoccurrence is the typical reason for death after cancer diagnosis. 5-Fluorouracil (5-FU) is the main chemostatic used in first line ...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-58386 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse muscle regeneration to define transcriptional regulatory pathways involved in muscle regeneration
Temporal expression profiling was utilized to define transcriptional regulatory pathways in vivo in a mouse muscle regeneration model. Potential downstream targets of MyoD were identified by temporal expression, promoter data base mining, and gel shift assays; Slug and calpain 6 were identified as n...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-469 | biostudies-arrayexpress
TranscriptomicsHuman cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo
Background: The biological mechanisms underlying cancer cell motility and invasiveness remain unclear, although it has been hypothesized that they involve some type of epithelial-mesenchymal transition (EMT). Methods: We used xenograft models of human cancer cells in immunocompromised mice, profili...
ORGANISM(S): Homo sapiens 
2011-12-29 | E-GEOD-34481 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression change due to knockdown of Slug expression in a basal-subtype breast cancer cell line, MCFDCIS.
Analysis of gene expression change due to knockdown of Slug expression in a basal-subtype breast cancer cell line, MCFDCIS. Total RNA isolated from MCFDCIS cells transfected with control or Slug specific siRNA.
ORGANISM(S): Homo sapiens 
2016-08-11 | E-GEOD-72011 | biostudies-arrayexpress
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