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MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
Metabolomics1H NMR metabolomic and transcriptomic analyses reveal urinary metabolites as biomarker candidates in response to protein undernutrition in adult rats

BACKGROUND: Protein undernutrition is prevalent mainly among elderly people, and it could develop diseases such as sarcopenia. Urinary metabolites may become biomarkers reflecting protein undernutrition, but this has been insufficiently investigated.

OBJECTIVE:

2021-05-27 | MTBLS1452 | MetaboLights
MetabolomicsMetabolic effects of the protein kinase R
Not available
ORGANISM(S): Mus musculus 
ST002412 | MetabolomicsWorkbench
TranscriptomicsExpression data from MDA-MB-231 parental and xenograft tumor cells treated with Smac mimetic SM-164.
Small-molecule Smac mimetics target inhibitor of apoptosis (IAP) proteins to induce TNFα-dependent apoptosis in cancer cells and several Smac mimetics have been advanced into clinical development as a new class of anticancer drugs. However, preclinical studies have shown that only a small subset of...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-33827 | biostudies-arrayexpress
MetabolomicsMetabolic signature of C-protein induced myositis mouse model
Not available
ORGANISM(S): Mus musculus 
ST002197 | MetabolomicsWorkbench
TranscriptomicsRIP-seq analysis of eukaryotic Sm proteins identifies three major categories of Sm-containing ribonucleoproteins
Background: Sm proteins are multimeric RNA-binding factors, found in all three domains of life. Eukaryotic Sm proteins, together with their associated RNAs, form small ribonucleoprotein (RNP) complexes important in multiple aspects of gene regulation. Comprehensive knowledge of the RNA components of...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-35842 | biostudies-arrayexpress
GenomicsIdentification of RNAs that can accept assembly of an Sm-protein ring
Identification of RNAs that can accept assembly of an Sm-protein ring
PRJNA1167748 | ENA
ProteomicsSM/J mice display spontaneous early onset disc degeneration link to ion transport system and matrisome changes
To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a good and bad intervertebral disc. Using a quantitative proteomic approach, we compared methodically the differences existing between a mo...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-16 | PXD008784 | Pride
Mouse intervertebral disc Nucleus pulposus Lg/j and sm/j. Proteomic 
GenomicsSMN and Symmetric Arginine Dimethylation of RNAP II CTD Control Termination
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit POLR2A is a platform for modifications specifying the recruitment of factors that regulate transcription, mRNA processing, and chromatin remodeling. Here, we show that a CTD arginine residue (R1810 in human) that is conserved acr...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73379 | biostudies-arrayexpress
ProteomicsThe Cystatin D Interactome Associated to Systemic Mastocytosis
he aim of the project is to characterize qualitatively and quantitatively the interaction of cystatin D in other protein partner and the formation of a complex in whole saliva of patients affected by different forms of systemic mastocytosis (SM), with and without skin involvement. The different comp...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042567 | Pride
Mastocytosis  high-resolution mass spectrometry  immunoprecipitation assay  cystatin d 
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