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TranscriptomicsExpression data from MDA-MB-231 parental and xenograft tumor cells treated with Smac mimetic SM-164.
Small-molecule Smac mimetics target inhibitor of apoptosis (IAP) proteins to induce TNFα-dependent apoptosis in cancer cells and several Smac mimetics have been advanced into clinical development as a new class of anticancer drugs. However, preclinical studies have shown that only a small subset of...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-33827 | biostudies-arrayexpress
UnknownSmac mimetic compounds potentiate interleukin-1beta-mediated cell death.
Not available
S-EPMC3003360 | biostudies-literature
UnknownSMG1 and NIK regulate apoptosis induced by Smac mimetic compounds.
Not available
S-EPMC3122057 | biostudies-literature
TranscriptomicsSMAC mimetics induce human macrophages to phagocytose live cancer cells
Macrophages engulf apoptotic bodies and cellular debris as part of homeostasis, but they can also phagocytosis live cells such as aged red blood cells. Pharmacologic reprogramming with the SMAC mimetic LCL-161 in combination with T cell-derived cytokines can induce macrophages to phagocytosis live c...
ORGANISM(S): Homo sapiens 
2024-11-30 | GSE282835 | GEO
UnknownInhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses.
Not available
S-EPMC5767188 | biostudies-literature
UnknownAstrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds.
Not available
S-EPMC11327263 | biostudies-literature
UnknownOncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model.
Not available
S-EPMC5356898 | biostudies-literature
GenomicsSMAC mimetics induce human macrophages to phagocytose live cancer cells
SMAC mimetics induce human macrophages to phagocytose live cancer cells
PRJNA1190496 | ENA
UnknownEnhanced glioblastoma immunotherapy via SMAC mimetic dose escalation and TGFβ blockade.
Not available
S-EPMC12901662 | biostudies-literature
UnknownSmac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.
Not available
S-EPMC5570934 | biostudies-literature
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