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GenomicsSmad3, Smad4 and TTF-1/NKX2-1 binding sites in H441/A549 lung cancer cell lines
We evaluated the role of TTF-1/NKX2-1 on Smad3 and Smad4 binding in lung cancer cell lines. Smad3 binding sites in A549 cells and Smad3, Smad4, and TTF-1/NKX2-1 binding sites in H441 cells were determined by ChIP-seq.
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-51509 | biostudies-arrayexpress
TranscriptomicsA global view on the role of SMAD4 gene in porcine follicular granulosa cells by RNA-Seq
Sma- and Mad-related protein 4 (SMAD4) is closely associated with the development of ovarian follicular. However, current knowledge of the genome-wide view on the role of SMAD4 gene in mammalian follicular granulosa cells (GCs) is still largely unknown. In the present study, RNA-Seq was performed to...
ORGANISM(S): Sus scrofa 
2016-07-25 | E-GEOD-76833 | biostudies-arrayexpress
TranscriptomicsAblation of Pten and Smad4 leads to metastatic lung carcinoma in a murine model.
Lung cancer is the leading cause of cancer related death in both men and women in the United States. Recently, Smad4 was discovered to be common somatic alteration in human squamous cell lung cancer. Our goal was to delineate the role of Smad4 in lung cancer. We have shown for the first time that t...
ORGANISM(S): Mus musculus 
2015-03-12 | E-GEOD-47116 | biostudies-arrayexpress
TranscriptomicsGene expression analyses of SMAD4 knockdown in pancreatic cell line
The transforming growth factor ? (TGF-?) signaling protein SMAD4 is lost in 60% of PDAC, and this has been associated with poorer prognosis. We expressed SMAD4 in human PDAC cell lines BxPC3, by selection of stable clones containing an inducible SMAD4 Tet-ON construct. After 24h of SMAD4 expression,...
ORGANISM(S): Homo sapiens 
2015-08-20 | E-GEOD-70940 | biostudies-arrayexpress
ProteomicsSMAD4-NFATc1 protein-protein interaction informed therapeutic vulnerability in SMAD4-deficient pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by a median survival rate of approximately six months. While genetic profiling has uncovered common mutations in PDAC, developing targeted therapeutic strategies remains challenging. SMAD4 is frequently mutated o...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD067749 | Pride
Smad4 Pancreatic cancer 
TranscriptomicsErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [expression]
Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with Squamous Cell Carcinoma has identified SMAD4 to be frequently mutated. Here we used a novel mouse model to determine the molecular mechanisms regulated by loss of Smad4 which lead to lung cance...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-57133 | biostudies-arrayexpress
TranscriptomicsSmad4 and Trim33 dependend nodal/activin responsive genes in differentiated mouse ESCs
In differentiated mouse ESCs, most of the nodal/activin responsive genes are dependent on both Smad4 and Trim33, some are solely dependent on Smad4, and some are dependent on Trim33. Ebs at Day2.5 from WT, Smad4 null, and Trim33 knock-down ESCs, were treated with activin or SB 431542 for 2 h.
ORGANISM(S): Mus musculus 
2012-01-09 | E-GEOD-32903 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mammary epithelial cell line MDA-MB-468 acking endogenous Smad4 nfected with either an adenovirus carrying GFP cDNA (control) or Smad4 cDNA (to restore the Smad4 activity in the cells). Cells were treated with TGF-b1 (0.5 ng/ml) or BMP-7 (300 ng/ml) for 2 or 12h
Identification of novel TGF-b1 and BMP-7-regulated genes in epithelial cells.

Human mammary epithelial cell line MDA-MB-468 that is lacking endogenous Smad4 was infected with either an adenovirus carrying GFP cDNA (control) or Smad4 cDNA (to restore the Smad4 activity in the cells). Cells w...
ORGANISM(S): Homo sapiens 
2004-03-15 | E-MEXP-78 | biostudies-arrayexpress
TranscriptomicsRole of TTF-1/NKX2-1, Smad3 and Smad4 on lung cancer cell lines
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-51510 | biostudies-arrayexpress
TranscriptomicsGene expression profile in platelets of mouse regulated by Smad4 gene
Mutations of SMAD family member 4 (Smad4) gene caused Hereditary Hemorrhagic Telangiectasia (HHT). It was believed that bleeding disorders were caused by arteriovenous malformation in this syndrome. Although several studies indicated dysfunction of platelets from HHT patient, the role(s) of smad4 in...
ORGANISM(S): Mus musculus 
2013-01-29 | E-GEOD-43814 | biostudies-arrayexpress
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