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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
MetabolomicsExtreme genome diversity and cryptic speciation in a harmful algal bloom forming eukaryote

Harmful algal blooms (HABs) of the toxic haptophyte Prymnesium parvum are a recurrent problem in many inland and estuarine waters around the world. Strains of P. parvum vary in the toxins they produce and in other physiological traits associated with HABs, but the genetic basis ...

2023-04-26 | MTBLS5893 | MetaboLights
GenomicsChIP-seq of Arabidopsis ARGONAUTE-small RNA interactions in Arabidopsis thaliana identified by high-throughput sequencing
The goal of this study was to identify small RNA-ARGONAUTE interactions in Arabidopsis. Co-immunoprecipitation assays followed by high-throughput sequencing were done to identify small RNA associated with HA-AGO2 and HA-AGO7. Experiment Overall Design: Sequencing-by-synthesis technology was used to ...
ORGANISM(S): Arabidopsis thaliana 
2009-08-30 | E-GEOD-12037 | biostudies-arrayexpress
TranscriptomicsPhysiological stressors and invasive plant infections alter the small RNA transcriptome of the rice blast fungus, Magnaporthe oryzae
The rice blast fungus, Magnaporthe oryzae is a destructive pathogen of rice and other related crops, causing significant yield losses worldwide. Endogenous small RNAs (sRNAs), including small interfering RNAs (siRNAs) and microRNAs (miRNAs) are critical components of gene regulation in many eukaryot...
ORGANISM(S): Oryza sativa 
2013-05-14 | E-GEOD-43277 | biostudies-arrayexpress
TranscriptomicsSmall RNA sequencing of plasma extracellular vesicles from HIV/HCV coinfected patients
We have analyzed six different extracelular vesicles isolation protocols from plasma of patients coinfected with human immunodeficiency virus and hepatitis C virus (HIV/HCV). In addition, two different RNA isolation kit were used for each protocol, one phenol-based and another pehenol-free kit. Same...
ORGANISM(S): Homo sapiens 
2020-08-14 | E-MTAB-8246 | biostudies-arrayexpress
TranscriptomicsAnalysis of microRNA proflie of peripheral blood mononuclear cells (PBMCs) in HIV-1 infected patients under different clinical status respect to hepatitis C virus (HCV) infection.
A total of 117 HIV-1 infected patients were analyzed. These individuals were categorized in three different groups according to their infectious status for HCV: A) HIV+/HCV+ group, (n=45) patients with HIV infection and active HCV-chronic infection naïve to any HCV treatment (positive PCR and positi...
ORGANISM(S): Homo sapiens 
2021-11-23 | E-MTAB-8274 | biostudies-arrayexpress
Transcriptomicssmall RNA sequencing from plasma samples of SARS-CoV-2 infected patients
High-throughput sequencing of the miRNAs present in plasma of COVID-19 patients at an early stage of the disease including non-SARS-CoV2 infected patients. This study allowed us to identify and functionally characterize human miRNAs associated with a worse evolution of the disease and a greater mort...
ORGANISM(S): Homo sapiens 
2022-04-03 | E-MTAB-10562 | biostudies-arrayexpress
ProteomicsProQ-associated small RNAs control motility in Vibrio cholerae
Gene regulation at the post-transcriptional level is prevalent in all domains of life. In bacteria, ProQ-like proteins have emerged as important RNA chaperones facilitating RNA stability and RNA duplex formation. In the major human pathogen V. cholerae, post-transcriptional gene regulation is key fo...
ORGANISM(S): Vibrio cholerae O1 biovar El Tor 
2025-01-06 | PXD055294 | Pride
In-gel digest Vibrio cholerae Bacteria Lc-ms/ms Flagellins 
TranscriptomicsRNA-sequencing of coding RNA from human purified intestinal epithelial samples and organoids derived from foetal and paediatric small and large intestine
Human intestinal epithelial organoids (IEO) culture models are rapidly emerging as novel experimental tools to investigate fundamental aspects of intestinal epithelial (patho)physiology. Cellular source and culture protocols vary between different IEO models and reliable markers for their characteri...
ORGANISM(S): Homo sapiens 
2018-01-20 | E-MTAB-5015 | biostudies-arrayexpress
TranscriptomicsLongitudinal miRNA sequencing study of HIV/HCV patients after HCV eradication with direct-acting antiviral (DAAs)
We have carried out a longitudinal study of PBMC's miRNA profile in HIV/HCV coinfected patients (n=28) after HCV eradication with DAA and SVR achivement. HIV monoinfected patients (n=16) were used as control. Briefly, peripheral venous blood samples were collected in EDTA tubes, and PBMCs were isol...
ORGANISM(S): Homo sapiens 
2021-11-23 | E-MTAB-10566 | biostudies-arrayexpress
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