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TranscriptomicsHigh-throughput sequencing of small RNAs from Xenopus tropicalis
High-throughput sequencing of small RNAs from Xenopus tropicalis (adult liver, adult skin, oocytes stage I, II, III, IV, V, VI). total RNA, ~18-42 nt RNAs isolated using PAGE, ligation to adapters requires 5' monophosphate and 3' OH Illumina/Solexa sequencing of adult liver, adult skin, oocytes stag...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2009-07-09 | E-GEOD-14952 | biostudies-arrayexpress
TranscriptomicsUnderstanding Vitamin D resistance using array comparative genomic hybridization
Vitamin D is the strongest known natural anti-proliferative. A large number of studies in a wide spectrum of cancers, including epidemiological, in vitro and animal models, demonstrate that the active form of Vitamin D has anti-cancer benefits, affecting both progression and metastasis. Alike the ro...
ORGANISM(S): Homo sapiens 
2008-05-31 | E-GEOD-9887 | biostudies-arrayexpress
TranscriptomicsA Systematic Substrate Screen Links Cyclin D-Dependent Kinases to Senescence Suppression in Cancer Cells through FOXM1
Gene expression (mRNA profiling) of U2OS osteosarcoma cells treated with 1 mM of the CDK4/6-specific inhibitor, PD0332991, versus vehicle (DMSO) for 4 hours Here, we monitored the early transcriptional response to acute inhibition of CDK4/6 catalytic activity. As PD0332991 substantially induced sene...
ORGANISM(S): Homo sapiens 
2011-11-18 | E-GEOD-32182 | biostudies-arrayexpress
TranscriptomicsReactivation of ERK signaling causes resistance to EGFR kinase inhibitors (SNP array)
The clinical efficacy of EGFR kinase inhibitors is limited by the development of drug resistance. The irreversible EGFR kinase inhibitor WZ4002 is effective against the most common mechanism of drug resistance mediated by the EGFR T790M mutation. Here we show that in multiple complementary models ha...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-37698 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing of Wild-Type FVB/NJ Mouse Cardiac Small RNA
Purpose: Next-generation sequencing (NGS) provides for quantitation of RNA abundances and comparison of RNA abundances within tissues and cells in a manner not possible with previous microarray technologies. We have made widespread use of Illumina sequencing technologies for RNA quantitation in seve...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55791 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing of Wild-Type FVB/NJ Mouse Cardiac Small RNA, after 1 week pressure overload
Purpose: Next-generation sequencing (NGS) provides for quantitation of RNA abundances and comparison of RNA abundances within tissues and cells in a manner not possible with previous microarray technologies. 5 female mice were subjected to a sham operation, and 5 female mice were subjected to transv...
ORGANISM(S): Mus musculus 
2014-04-18 | E-GEOD-56891 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing of Wild-Type C57BL/6J Mouse Cardiac Small RNA
Purpose: Next-generation sequencing (NGS) provides for quantitation of RNA abundances and comparison of RNA abundances within tissues and cells in a manner not possible with previous microarray technologies. We have made widespread use of Illumina sequencing technologies for RNA quantitation in seve...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55789 | biostudies-arrayexpress
TranscriptomicsControl of RNA stability by NrrF, an iron-regulated small RNA in Neisseria gonorrhoeae.
Regulation of gene expression by small non-coding RNAs (sRNAs) plays a critical role in bacterial response to physiological stresses. NrrF, a trans-acting sRNA in Neisseria meningitidis and Neisseria gonorrhoeae, has been shown in the meningococcus to indirectly control, in response to iron (Fe) av...
ORGANISM(S): Neisseria gonorrhoeae 
2013-09-27 | E-GEOD-48526 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression changes associated with specific STAT3 activation
Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor in cancer. However, while the protein-coding target genes of STAT3 have been extensively studied, the microRNA target genes of STAT3 are less understood. MicroRNAs are short, non-coding RNAs that regulate m...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-44089 | biostudies-arrayexpress
TranscriptomicsmiRNA arrays for LPS-activated Akt1+/+ and Akt1-/- macrophages
MicroRNAs regulated by lipopolysaccharide (LPS) target genes that contribute to the inflammatory phenotype. Here we showed that the protein kinase Akt1, which is activated by LPS, positively regulated miRNAs let-7e, miR-181c but negatively regulated miR-155 and miR-125b. In silico analyses and trans...
ORGANISM(S): Mus musculus 
2009-08-21 | E-GEOD-17421 | biostudies-arrayexpress
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