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TranscriptomicsEndogenous shRNAs, siRNAs, and Other Microprocessor-independent, Dicer-dependent Small RNAs in Mouse ES Cells
Canonical microRNAs (miRNAs) require two processing steps: the first by the Microprocessor, a complex of DGCR8 and Drosha, and the second by Dicer. dgcr8delta/delta mouse embryonic stem cells (mESCs) have less severe phenotypes than dicer1delta/delta mESCs, suggesting a physiological role for Microp...
ORGANISM(S): Mus musculus 
2008-09-09 | E-GEOD-12521 | biostudies-arrayexpress
TranscriptomicsImprinted expression of genes and small RNA is triggered by localized demethylation of the maternal genome in rice endosperm
We report that rice endosperm shows a specific hypomethylation of DNA in the maternal genome, preferring regions of high DNA accessibility. Maternally expressed imprinted genes are enriched for hypomethylation at putative promoter regions and transcriptional termini, and paternally expressed genes a...
ORGANISM(S): Oryza sativa 
2013-05-01 | E-GEOD-44898 | biostudies-arrayexpress
TranscriptomicsDynamics and Characterization of Small RNAs of Virus and Host Origin from Wheat Streak Mosaic Virus- and/or Triticum Mosaic Virus-infected Susceptible and Temperature-Sensitive Resistant Wheat Cultivars
Wheat streak mosaic virus (WSMV) and Triticum mosaic virus (TriMV) are type members of Tritimovirus and Poacevirus genera, respectively, in the family Potyviridae, and are transmitted by wheat curl mites. Co-infection of these two viruses causes synergistic interaction with increased virus accumula...
ORGANISM(S): Triticum aestivum 
2014-12-01 | E-GEOD-54026 | biostudies-arrayexpress
TranscriptomicsMammalian microRNAs: Experimental evaluation of novel and previously annotated genes
MicroRNAs (miRNAs) are small regulatory RNAs that derive from distinctive hairpin transcripts. To learn more about the miRNAs of mammals, we sequenced 60 million small RNAs from mouse brain, ovary, testes, embryonic stem cells, three embryonic stages, and whole newborns. Analysis of these sequences ...
ORGANISM(S): Homo sapiens 
2010-04-26 | E-GEOD-20384 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of entire small intestines of control and CFTR null mice congenic on the C57Bl6 background to study the inflammation of cystic fibrosis mouse small intestine.
Total RNA was prepared from the entire small intestines of 40 day old Control and CFTR null mice (2 males and 1 female of each genotype), congenic on the black6 background, using TRIzol reagent. Mice were fed Peptamen from age 10 days to prevent intestinal obstruction.
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-765 | biostudies-arrayexpress
TranscriptomicsFunctional non-canonical microRNAs in the mammalian hippocampus and cortex
Non-canonical microRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) are distinct subclasses of small RNAs that bypass the DGCR8/Drosha Microprocessor but still require Dicer for their biogenesis. What, if any, role they have in mammals remains unknown. To identify potential roles for t...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-21090 | biostudies-arrayexpress
UnknownStatistical image properties and aesthetic judgments on abstract paintings by Robert Pepperell.
Not available
S-EPMC10241310 | biostudies-literature
TranscriptomicsLubiprostone effects on small intestinal gene expression in wild type and Cftr-null mice
Background: Cystic fibrosis (CF) is caused by mutations in the CFTR gene that impair function of this cAMP-regulated Cl- channel. In the small intestine, loss of CFTR function creates a dehydrated, acidic luminal environment which is believed to cause an accumulation of mucus, a phenotype characteri...
ORGANISM(S): Mus musculus 
2010-09-20 | E-GEOD-18327 | biostudies-arrayexpress
GenomicsGenentech Small Cell Lung Cancer (SCLC) Screen
Exome capture, RNA-Seq, whole genome sequencing of set of Small Cell Lung Cancer samples.
EGAS00001000334 | EGA
TranscriptomicsMLL Fusion Proteins Preferentially Regulate a Small Set of Wild Type MLL Target Genes in the Leukemic Genome
MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations encode chimeric MLL fusions that act as potent drivers of acute leukemia. However, it remains unclear what portion of the leukemic genome is un...
ORGANISM(S): Mus musculus 
2011-04-28 | E-GEOD-24794 | biostudies-arrayexpress
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