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MetabolomicsCombined functional genomic and metabolomic approaches identify new genes required for growth in human urine by multidrug resistant Escherichia coli ST131
Urinary tract infections (UTIs) are one of the most common bacterial infections in humans, with ~400 million cases across the globe each year. Uropathogenic E. coli (UPEC) is the major cause of UTI and increasingly associated with antibiotic resistance. This scenario has been worsened by the emergen...
2024-02-09 | MTBLS9131 | MetaboLights
TranscriptomicsCellular Transcriptional Responses to Merkel cell polyomavirus T antigens
Merkel cell polyomavirus (MCV) is clonally integrated in over 80% of Merkel cell carcinomas and mediates tumor development through the expression of viral oncoproteins large T (LT) and small T antigens (sT). Viral integration is associated with signature mutations in the T antigen locus that result ...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-68503 | biostudies-arrayexpress
ProteomicsMudPIT analysis of STRN4 interacting proteins from HEK TER cells expressing either SV40 ST or GFP
HEK TER cells expressing either SV40 ST or GFP (30 x 15-cm diameter plates) were harvested with lysis buffer (20 mM imidazole HCl, 2 mM EDTA, 2 mM EGTA, pH 7.0 with 10 ug/mL each of aprotinin, leupeptin, pepstatin, 1 mM benzamidine, and 1 mM PMSF). The clarified cell extract was incubated overnight ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-12-05 | MSV000084662 | MassIVE
MetabolomicsMetabolic analysis of the response of Pseudomonas putida DOT-T1E strains to toluene using Fourier transform infrared spectroscopy and gas chromatography mass spectrometry
To elucidate any observable metabolic alterations during interactions of several strains of Pseudomonas putida (DOT-T1E, and its mutants DOT-T1E-PS28 and DOT-T1E-18) with the aromatic hydrocarbon toluene, metabolomic approaches were employed. Initially, Fourier-transform infrared (FT-IR) spectroscop...
2016-08-23 | MTBLS319 | MetaboLights
TranscriptomicsExpression data from WT and TCF-1-deficient memory CD8 T cells
TCF-1 is an HMG family transcription factor which is known to be activated by the canonical Wnt signaling pathway and modulated by other signals such as those derived from T cell receptor. We found that during CD8 T cell responses, TCF-1 deficiency impaired long-term maintenance of antigen-specific ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-20754 | biostudies-arrayexpress
MetabolomicsMetabolomics analysis reveals the participation of efflux pumps and ornithine in the response of Pseudomonas putida DOT-T1E cells to challenge with propranolol
Efflux pumps are critically important membrane components that play a crucial role in strain tolerance in Pseudomonas putida to antibiotics and aromatic hydrocarbons that result in these toxicants being expelled from the bacteria. Here, the effect of propranolol on P. putida was examined by sudden a...
2016-08-23 | MTBLS320 | MetaboLights
TranscriptomicsWhole-transcript expression data from normal and DLBCL human peripheral blood samples
Gene expression profiling based classification of DLBCL patients versus healthy donors provides insights on transcriptional regulation processes. Within the most represented pathways in DLBCL, we identified an innate immune response signature, as well as an anti-inflammatory response. On the other h...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-83632 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human serum starvation cell lines for 24hrs, 4 cell types - TERV, TERV-ST, TERV-ST110, TERV-ASB56
Study the effects of serum starvation for 24hrs on 4 cell types - TERV, TERV-ST, TERV-ST110, TERV-ASB56.
ORGANISM(S): Homo sapiens 
2004-10-01 | E-MEXP-156 | biostudies-arrayexpress
TranscriptomicsWhole-genome microarray analysis of primary, secondary, tertiary and quaternary memory CD8 T cells
The transcriptome of naive OT-I T cells was compared to memory CD8 T cells after 1, 2, 3, or 4 infection with ovalbumin expressing Listeria monocytogenes (LM-OVA). Naive Thy1.1 OT-I T cells were adoptively transferred into Thy1.2 naive hosts prior to infection with LM-OVA. The resulting memory CD8 T...
ORGANISM(S): Mus musculus 
2010-07-09 | E-GEOD-21360 | biostudies-arrayexpress
TranscriptomicsGene signature of CLL cells cultured with activated T cells or CD40L-expressing cells
Chronic Lymphocytic Leukemia (CLL) cells multiply in secondary lymphoid tissue but the mechanisms leading to their proliferation are still uncertain. In addition to BCR-triggered signals, other microenvironmental factors might well be involved. In proliferation centres, leukemic B cells are in close...
ORGANISM(S): Homo sapiens 
2013-10-07 | E-GEOD-50572 | biostudies-arrayexpress
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